Research and practice in critical care medicine have long been defined by syndromes,
which, despite being clinically recognizable entities, are, in fact, loose amalgams of …

Background Studies that have evaluated the use of intravenous vitamin C in adults with
sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) have shown …

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of any publisher or professional medical society. This document has not been endorsed by …

Prediction models aim to use available data to predict a health state or outcome that has not
yet been observed. Prediction is primarily relevant to clinical practice, but is also used in …

Background Clinical outcome prediction normally employs static, one-size-fits-all models that
perform well for the average patient but are sub-optimal for individual patients with unique …

Sepsis is a complex inflammatory response to infection. Microarray-based gene expression
studies of sepsis have illuminated the complex pathogen recognition and inflammatory …

Background As the sensing capabilities of wearable devices improve, there is increasing
interest in their application in medical settings. Capabilities such as heart rate monitoring may …

Background In Africa, an estimated 300-500 million cases of malaria occur each year resulting
in approximately 1 million deaths. More than 90% of these are in children under 5 years …

Objective: This study aims to explore the role of blockchain in supporting clinical trials data
management and develop a proof-of-concept implementation of a patient-facing and …

Precision medicine is increasingly touted as a groundbreaking new paradigm in biomedicine.
In the ICU, the complexity and ambiguity of critical illness syndromes have been identified …