The guideline was developed according to the Appraisal of Guidelines, Research and
Evaluation (AGREE II) framework, 6 which provides a rigorous, evidence-based approach. The …

Eukaryotic cells compartmentalize biochemical processes in different organelles, often
relying on metabolic cycles to shuttle reducing equivalents across intracellular membranes. …

Adipose tissue plays important roles in regulating carbohydrate and lipid homeostasis, but
less is known about the regulation of amino acid metabolism in adipocytes. Here we applied …

Benign hepatosteatosis, affected by lipid uptake, de novo lipogenesis and fatty acid (FA)
oxidation, progresses to non-alcoholic steatohepatitis (NASH) on stress and inflammation. A …

Pyruvate lies at a central biochemical node connecting carbohydrate, amino acid, and fatty
acid metabolism, and the regulation of pyruvate flux into mitochondria represents a critical …

Oncogenic mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in several types of
cancer, but the metabolic consequences of these genetic changes are not fully understood. …

Diabetes represents a spectrum of disease in which metabolic dysfunction damages multiple
organ systems including liver, kidneys and peripheral nerves 1 , 2 . Although the onset and …

Fatty acid synthase (FASN) predominantly generates straight-chain fatty acids using acetyl-CoA
as the initiating substrate. However, monomethyl branched-chain fatty acids (mmBCFAs) …

Cardiovascular disease (CVD) is the leading cause of premature death for women in
Canada. 1 Although it has long been recognized that estrogen impacts vascular responses in …

Background & Aims Known genetic factors explain only a small fraction of genetic variation
in colorectal cancer (CRC). We conducted a genome-wide association study to identify risk …