User profiles for Christian Saliba

Christian Saliba

University of Cagliari, University of Malta
Verified email at um.edu.mt
Cited by 4950

SARS-CoV-2 B. 1.617. 2 Delta variant replication and immune evasion

…, JH Lee, J Bassi, C Silacci-Fegni, C Saliba… - Nature, 2021 - nature.com
The B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
was first identified in the state of Maharashtra in late 2020 and spread throughout India, …

SARS-CoV-2 immune evasion by the B. 1.427/B. 1.429 variant of concern

…, MA Tortorici, MJ Navarro, C Silacci-Fregni, C Saliba… - Science, 2021 - science.org
A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429), which was originally
detected in California, carries spike glycoprotein mutations S13I in the signal peptide, W152C …

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

E Cameroni, JE Bowen, LE Rosen, C Saliba… - Nature, 2022 - nature.com
The recently emerged SARS-CoV-2 Omicron variant encodes 37 amino acid substitutions in
the spike protein, 15 of which are in the receptor-binding domain (RBD), thereby raising …

Imprinted antibody responses against SARS-CoV-2 Omicron sublineages

…, JE Bowen, C Stewart, M Giurdanella, C Saliba… - Science, 2022 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages carry
distinct spike mutations resulting in escape from antibodies induced by previous infection or …

Broad sarbecovirus neutralization by a human monoclonal antibody

…, A Addetia, B Guarino, K Culap, N Sprugasci, C Saliba… - Nature, 2021 - nature.com
The recent emergence of SARS-CoV-2 variants of concern 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 – 10
and the recurrent spillovers of coronaviruses 11 , 12 into the human population highlight the …

Recurrent emergence and transmission of a SARS-CoV-2 spike deletion H69/V70

…, JC Kenyon, AM Lever, A De Marco, C Saliba… - BioRxiv, 2020 - biorxiv.org
SARS-CoV-2 amino acid replacements in the receptor binding domain (RBD) occur
relatively frequently and some have a consequence for immune recognition. Here we report …

Neutralization, effector function and immune imprinting of Omicron variants

…, R Acosta, D Johnson, S Subramanian, C Saliba… - Nature, 2023 - nature.com
Currently circulating SARS-CoV-2 variants have acquired convergent mutations at hot spots
in the receptor-binding domain 1 (RBD) of the spike protein. The effects of these mutations …

The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2

…, S Subramanian, B Sloan, S Bianchi, D Pinto, C Saliba… - biorxiv, 2021 - biorxiv.org
VIR-7831 and VIR-7832 are dual action monoclonal antibodies (mAbs) targeting the spike
glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). VIR-7831 …

[HTML][HTML] SARS-CoV-2 B. 1.617. 2 Delta variant replication, sensitivity to neutralising antibodies and vaccine breakthrough

…, JH Lee, J Bassi, C Silacci-Fegni, C Saliba… - 2021 - europepmc.org
The SARS-CoV-2 B. 1.617. 2 (Delta) variant was first identified in the state of Maharashtra in
late 2020 and spread throughout India, outcompeting pre-existing lineages including B. …

Yes‐associated protein regulation of adaptive liver enlargement and hepatocellular carcinoma development in mice

MA Kowalik, C Saliba, M Pibiri, A Perra… - …, 2011 - Wiley Online Library
The Hippo kinase cascade, a growth‐suppressive pathway that ultimately antagonizes the
transcriptional coactivator Yes‐associated protein (YAP), has been shown in transgenic …