Purpose Prognostic and predictive factors are well established in early-stage breast cancer,
but less is known about which metastatic sites will be affected. Methods Patients with early-…

Purpose Adjuvant! ( www.adjuvantonline.com ) is a web-based tool that predicts 10-year
breast cancer outcomes with and without adjuvant systemic therapy, but it has not been …

BACKGROUND. Over the past decade, a number of new therapeutic agents have become
available in the treatment of metastatic breast cancer (MBC). This study characterized the use …

… Conception and design: Caroline Lohrisch, Karen Gelmon, Ivo A. Olivotto Collection and
assembly of data: Caroline Speers, Suzanne Taylor, Jeff Barnett Data analysis and …

Purpose Human epidermal growth factor receptor 2 gene (HER2) is associated with a
poorer outcome in node-positive breast cancer, but the results are conflicting in node-negative …

Purpose We hypothesized different Overall Survival (OS) in metastatic breast cancer (MBC)
after relapse vs de novo presentation. Methods We identified women in British Columbia …

Purpose Estrogen receptor (ER) expression predicts improved breast cancer–specific
survival and reduced risk of recurrence and is targeted in breast cancer therapy. A high-quality …

Purpose To determine whether the patterns of relapse according to estrogen receptor (ER)
and human epidermal growth factor receptor 2 (HER2) status changed in the contemporary …

Purpose To discuss the absolute benefits from adjuvant systemic therapy knowledge of long-term
outcomes and baseline risks of relapse and disease-specific survival are required. We …

Purpose: To define the individual factors and combinations of factors associated with
increased risk of locoregional recurrence (LRR) that may justify postmastectomy radiotherapy (…