Immunotherapy for cancer treatment continues to evolve, and immune checkpoints have
proven successful therapeutic targets. With success has come the challenge of managing the …

Massive pulmonary gangrene is a rare complication of pneumonia, particularly in the
postantibiotic era. We report two cases of community-acquired Streptococcus pneumoniae …

Objective. To determine the timeliness of consultation and initiation of disease-modifying
antirheumatic drugs (DMARD) in patients with rheumatoid arthritis (RA) referred to …

Objective To compare the European League Against Rheumatism (EULAR) and Simplified
Disease Activity Index 50% (SDAI50) response measures (RMs) and their impact on future …

CRAJ 2013• Volume 23, Number 3 24a several countries including Germany and Italy. In a
recent questionnaire, it was recently reported that 80% of German rheumatologists use MSK …

Objective. To evaluate the prevalence and predictive factors of sustained remission in an
early rheumatoid arthritis (ERA) population. Predictive factors of sustained remission in ERA …

DISCUSSION Severe community-acquired pneumonia still has a mortality of between 29 and
54 percent, despite intensive care and appropriate antibiotic therapy. A number of factors, …

Objective. Rheumatoid factor (RF) and anticitrullinated protein antibodies (ACPA) are
believed to be associated with more severe rheumatoid arthritis; however, studies in early …

Objective To evaluate the reliability of concurrent flare identification using 3 methods (patient,
rheumatologist and Disease Activity Score (DAS)28 criteria), and construct validity of …

Objectives The mechanism of action of methotrexate in rheumatoid arthritis (RA) is complex.
It may increase adenosine levels by blocking its conversion to uric acid (UA). This study was …