Burns are one of the most common and devastating forms of trauma. Patients with serious
thermal injury require immediate specialized care in order to minimize morbidity and mortality. …

Background Mesenchymal stromal cells (MSCs, “adult stem cells”) have been widely used
experimentally in a variety of clinical contexts. There is interest in using these cells in critical …

The neuromodulator adenosine regulates immune activation and neuronal survival through
specific G-protein-coupled receptors expressed on macrophages and neurons, including the …

Rationale: Septic shock is a significant cause of morbidity and mortality in the pediatric
population. Early recognition of septic shock and appropriate treatment increase survival rate; thus…

Background Characterization of the mesenchymal stromal cell (MSC) safety profile is important
as this novel therapy continues to be evaluated in clinical trials for various inflammatory …

Rationale: In septic animal models mesenchymal stem (stromal) cells (MSCs) modulate
inflammation, enhance tissue repair and pathogen clearance, and reduce death. Objectives: To …

Sepsis-associated encephalopathy manifesting as delirium is a common problem in critical
care medicine. In this study, patients that had delirium due to sepsis had significant cognitive …

Background: Aboriginal Canadians are considered to be at increased risk of major trauma.
However, population-based studies characterizing the distribution, determinants and …

Idiopathic pulmonary fibrosis (IPF) is a lung disease that is characterized by epithelial cell
damage and areas of denuded basement membrane resulting in inflammation, fibroblast …

The lung naturally resists Aspergillus fumigatus (Af) in healthy individuals, but multiple
conditions can disrupt this resistance, leading to lethal invasive infections. Core processes of …