Background In countries of high endemicity of the soil-transmitted helminth parasites Ascaris
lumbricoides , Trichuris trichiura , and hookworm, preventive chemotherapy (ie, repeated …

Background Interpretation of the evidence from randomised controlled trials (RCTs) of
remdesivir in patients treated in hospital for COVID-19 is conflicting. We aimed to assess the …

Helminth infections are responsible for a considerable public health burden, yet the current
drug armamentarium is small. Given the high cost of drug discovery and development, the …

Background Pathogenic intestinal protozoa infections are responsible for substantial mortality
and morbidity, particularly in settings where people lack improved sanitation and safe …

Background. Single-dose albendazole and mebendazole show limited efficacy in the treatment
of trichuriasis. The combination of albendazole with ivermectin improves efficacy, but a …

Background The Kato-Katz technique is widely used for the diagnosis of soil-transmitted
helminthiasis in epidemiological surveys and is believed to be an inexpensive method. The …

Background Describe and evaluate the methodological conduct of prognostic prediction
models developed using machine learning methods in oncology. Methods We conducted a …

Background Existing anthelmintic drugs (eg, albendazole and mebendazole) have low
efficacy against the intestinal nematode species Trichuris trichiura and the drug pipeline is …

Objectives Randomized clinical trials (RCTs) are costly. We aimed to provide a systematic
overview of the available evidence on resource use and costs for RCTs to support budget …

Objective Evaluate the completeness of reporting of prognostic prediction models developed
using machine learning methods in the field of oncology. Study design and setting We …