Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody
…, K Culap, F Zatta, A De Marco, A Peter, B Guarino… - Nature, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged
coronavirus that is responsible for the current pandemic of coronavirus disease 2019 (COVID-19), …
coronavirus that is responsible for the current pandemic of coronavirus disease 2019 (COVID-19), …
[PDF][PDF] Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology
…, LE Rosen, JE Bowen, OJ Acton, S Jaconi, B Guarino… - Cell, 2020 - cell.com
Analysis of the specificity and kinetics of neutralizing antibodies (nAbs) elicited by SARS-CoV-2
infection is crucial for understanding immune protection and identifying targets for …
infection is crucial for understanding immune protection and identifying targets for …
Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms
…, A Minola, S Jaconi, F Zatta, A De Marco, B Guarino… - Science, 2020 - science.org
Efficient therapeutic options are needed to control the spread of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) that has caused more than 922,000 fatalities as of 13 …
syndrome coronavirus 2 (SARS-CoV-2) that has caused more than 922,000 fatalities as of 13 …
[PDF][PDF] N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2
The SARS-CoV-2 spike (S) glycoprotein contains an immunodominant receptor-binding
domain (RBD) targeted by most neutralizing antibodies (Abs) in COVID-19 patient plasma. Little …
domain (RBD) targeted by most neutralizing antibodies (Abs) in COVID-19 patient plasma. Little …
Broad betacoronavirus neutralization by a stem helix–specific human antibody
The spillovers of betacoronaviruses in humans and the emergence of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) variants highlight the need for broad coronavirus …
syndrome coronavirus 2 (SARS-CoV-2) variants highlight the need for broad coronavirus …
Imprinted antibody responses against SARS-CoV-2 Omicron sublineages
…, C Stewart, M Giurdanella, C Saliba, B Guarino… - Science, 2022 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages carry
distinct spike mutations resulting in escape from antibodies induced by previous infection or …
distinct spike mutations resulting in escape from antibodies induced by previous infection or …
Broad sarbecovirus neutralization by a human monoclonal antibody
The recent emergence of SARS-CoV-2 variants of concern 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 – 10
and the recurrent spillovers of coronaviruses 11 , 12 into the human population highlight the …
and the recurrent spillovers of coronaviruses 11 , 12 into the human population highlight the …
The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2
…, FA Lempp, D Ma, MA Schmid, ML Agostini, B Guarino… - biorxiv, 2021 - biorxiv.org
VIR-7831 and VIR-7832 are dual action monoclonal antibodies (mAbs) targeting the spike
glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). VIR-7831 …
glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). VIR-7831 …
[PDF][PDF] Structure and function analysis of an antibody recognizing all influenza A subtypes
…, PA Walker, MK Vorlaender, S Bianchi, B Guarino… - Cell, 2016 - cell.com
Influenza virus remains a threat because of its ability to evade vaccine-induced immune
responses due to antigenic drift. Here, we describe the isolation, evolution, and structure of a …
responses due to antigenic drift. Here, we describe the isolation, evolution, and structure of a …
Neutralization, effector function and immune imprinting of Omicron variants
Currently circulating SARS-CoV-2 variants have acquired convergent mutations at hot spots
in the receptor-binding domain 1 (RBD) of the spike protein. The effects of these mutations …
in the receptor-binding domain 1 (RBD) of the spike protein. The effects of these mutations …