Animal cells control their membrane lipid composition within narrow limits, but the sensing
mechanisms underlying this control are largely unknown. Recent studies disclosed a protein …

Cholesterol synthesis in animals is controlled by the regulated transport of sterol regulatory
element-binding proteins (SREBPs) from the endoplasmic reticulum to the Golgi, where the …

10.7554/eLife.25466.001 Cells employ regulated transport mechanisms to ensure that their
plasma membranes (PMs) are optimally supplied with cholesterol derived from uptake of low-…

Scap is a polytopic membrane protein that functions as a molecular machine to control the
cholesterol content of membranes in mammalian cells. In the 21 years since our laboratory …

The Hedgehog (Hh) signaling pathway coordinates cell–cell communication in development
and regeneration. Defects in this pathway underlie diseases ranging from birth defects to …

Egress of lipoprotein-derived cholesterol from lysosomes requires two lysosomal proteins,
polytopic membrane-bound Niemann–Pick C1 (NPC1) and soluble Niemann–Pick C2 (NPC2)…

There is overwhelming evidence that lipid bilayer regions of animal cell membranes are in a
liquid state. Quantitative models of these bilayer regions must then be models of liquids. …

Mammalian cells control their membrane composition by regulating the vesicular transport
of membrane-bound sterol regulatory element binding proteins (SREBPs) from endoplasmic …

10.7554/eLife.02882.001 When human fibroblasts take up plasma low density lipoprotein (LDL),
its cholesterol is liberated in lysosomes and eventually reaches the endoplasmic …

Given the increasing penetration and health care related use of the Internet, we examined
the evidence on the impact of Internet-based interventions on pain. A search of Medline, …