Osteoporosis results from an imbalance in skeletal remodeling that favors bone resorption
over bone formation. Bone matrix is degraded by osteoclasts, which differentiate from myeloid …

VIR-7831 and VIR-7832 are dual action monoclonal antibodies (mAbs) targeting the spike
glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). VIR-7831 …

Viruses have long been considered potential triggers of autoimmune diseases. Here we
defined the intestinal virome from birth to the development of autoimmunity in children at risk for …

Zoonotic transmission of lethal henipaviruses (HNVs) from their natural fruit bat reservoirs to
humans has only been reported in Australia and South/Southeast Asia. However, a recent …

Determinants of protective immunity against severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) infection require the development of well-standardized, reproducible …

Paramyxoviruses are known to replicate in the cytoplasm and bud from the plasma membrane.
Matrix is the major structural protein in paramyxoviruses that mediates viral assembly and …

Nipah and Hendra viruses are recently emerged bat-borne paramyxoviruses (genus
Henipavirus) causing severe encephalitis and respiratory disease in humans with fatality rates …

For efficient replication, viruses have developed mechanisms to evade innate immune
responses, including the antiviral type-I interferon (IFN-I) system. Nipah virus (NiV), a highly …

Tuberculosis remains a major global health problem that kills up to 2 million people annually.
Central to the success of Mycobacterium tuberculosis (Mtb) as a pathogen is its ability to …

The paramyxovirus matrix (M) protein is a molecular scaffold required for viral morphogenesis
and budding at the plasma membrane. Transient nuclear residence of some M proteins …