Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …

Stratification of women according to their risk of breast cancer based on polygenic risk scores
(PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, …

Night shift work has been suspected to increase breast cancer risk but epidemiological studies
have been inconsistent due to heterogeneous assessment of exposure to night work. To …

Objectives Long-term night work has been suggested as a risk factor for breast cancer;
however, additional studies with more comprehensive methods of exposure assessment to …

Genome-wide association studies have identified breast cancer risk variants in over 150
genomic regions, but the mechanisms underlying risk remain largely unknown. These regions …

Long-term, night shiftwork has been identified as a potential carcinogenic risk factor. It is
hypothesized that increased light at night exposure during shiftwork reduces melatonin …

… Anne Grundy was supported by a postdoctoral fellowship from Cancer Care Ontario. The
funders had no role in study design, data collection and analysis, decision to publish, or …

Background: Shift work has been identified as a risk factor for several cancer sites in recent
years, with melatonin as a potential intermediate on the proposed causal pathway. This study …

Objective To estimate the association between occupational polycyclic aromatic hydrocarbon
(PAH) exposure and female breast cancer. Methods Lifetime work histories for 1130 cases …

Experimental and epidemiologic studies suggest that light at night (LAN) exposure disrupts
circadian rhythm, and this disruption may increase breast cancer risk. We investigated the …