The International Symposium on Biomedical Imaging (ISBI) held a grand challenge to evaluate
computational systems for the automated detection of metastatic breast cancer in whole …

Importance Application of deep learning algorithms to whole-slide pathology images can
potentially improve diagnostic accuracy and efficiency. Objective Assess the performance of …

In this white paper, experts from the Digital Pathology Association (DPA) define terminology
and concepts in the emerging field of computational pathology, with a focus on its …

The morphological interpretation of histologic sections forms the basis of diagnosis and
prognostication for cancer. In the diagnosis of carcinomas, pathologists perform a …

Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive
breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, …

Chromosomal translocations encode oncogenic fusion proteins that have been proven to be
causally involved in tumorigenesis. Our understanding of whether such genomic alterations …

Two large-scale pharmacogenomic studies were published recently in this journal. Genomic
data are well correlated between studies; however, the measured drug response data are …

MEDICAL EDUCATION IN THE UNITED STATES TODAY IS STRIK-ingly standardized and
demanding. It was not always so. Prior to the widespread implementation of educational …

Genes encoding components of the PI3K–AKT–mTOR signaling axis are frequently mutated
in cancer, but few mutations have been characterized in MTOR, the gene encoding the …

Stromal cells within the tumor microenvironment are essential for tumor progression and
metastasis. Surprisingly little is known about the factors that drive the transcriptional …