Background: SGLT2 (sodium-glucose cotransporter 2) inhibitors lower cardiovascular events
in type 2 diabetes mellitus but whether they promote direct cardiac effects remains unknown…

Background—Adropin is a recently identified protein that has been implicated in the maintenance
of energy homeostasis and insulin resistance. Because vascular function and insulin …

The endothelium plays a central role in the maintenance of vascular homeostasis. One of
the main effectors of endothelial dysfunction is ANG II, and pharmacological approaches to …

Background— MicroRNA are essential posttranscriptional modulators of gene expression
implicated in various chronic diseases. Because microRNA-145 is highly expressed in …

A, EPO levels in patients receiving empagliflozin 10 mg daily (red circles) or placebo (blue
squares) plotted as mean±95% CIs. Adjusted differences are betweengroup differences in …

Altered macrophage kinetics is a pivotal mechanism of visceral obesity-induced inflammation
and cardiometabolic risk. Because monocytes can differentiate into either proatherogenic …

Improving endothelial nitric oxide synthase (eNOS) bioactivity and endothelial function is
important to limit native, vein graft, and transplant atherosclerosis. Visfatin, a NAD biosynthetic …

The tumour suppressor BRCA1 is mutated in familial breast and ovarian cancer but its role
in protecting other tissues from DNA damage has not been explored. Here we show a new …

The physiological role of autophagic flux within the vascular endothelial layer remains
poorly understood. Here, we show that in primary endothelial cells, oxidized and native LDL …

OBJECTIVE: Bone morphogenetic protein-2 (BMP-2) is a major regulator of aortic valve
calcification. MicroRNAs (miRNAs) are essential post-transcriptional modulators of gene …