Abstract This second Guideline for Reasonable and Appropriate Care in the Emergency
Department (GRACE‐2) from the Society for Academic Emergency Medicine is on the topic …

Introduction: There are concerns that opioids may be associated with an increased risk of
infection. This safety issue is alarming given the widespread use of opioids in pain …

Background Although little is known about why opioid prescribing practices differ between
physicians, clinical competence, specialty training and country of origin may play a role. We …

Low back pain is a leading cause of disability globally. It is a common reason for
presentation to the emergency department where opioids are commonly prescribed. This is …

Objectives: Outline the toxicokinetics and pathophysiology of opioid toxicity. Review the
evaluation procedures for diagnosing opioid toxicity. Describe both the pharmacological and …

This paper is the forty-first consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Purpose Reducing initial exposure of “opioid naïve” patients to opioids is a public health
priority. Identifying opioid naïve patients is difficult, as numerous definitions are used. The …

Background Exposure to opioid analgesics have historically raised concern for a risk of
developing opioid use disorder. Prescriber audit-and-feedback interventions may reduce …

Objective To quantify unused opioids among adult and pediatric patients discharged from
the emergency department (ED) or ambulatory care settings with a prescription for acute …

Background: Deaths related to opioid overdoses are increasing in North America, with the
emergency department being identified as a potential contributor toward this epidemic. Our …