Economic evidence is increasingly being used for informing health policies. However, the
underlining principles of health economic analyses are not always fully understood by non-…

Introduction: Evidence-based psychotherapies for borderline personality disorder (BPD) are
lengthy, posing a barrier to their access. Brief psychotherapy may achieve comparable …

BACKGROUND Many western countries have established female human papillomavirus (HPV)
vaccination programs for the prevention of cervical cancer. The quadrivalent HPV …

Real-world effectiveness studies are important for monitoring performance of COVID-19
vaccination programmes and informing COVID-19 prevention and control policies. We aimed to …

Although the burden of hepatocellular carcinoma (HCC) is an escalating public health
problem, it has not been rigorously estimated within a Canadian context. We conducted a …

Background Although Dialectical Behaviour Therapy (DBT) is an evidence-based psychosocial
treatment for borderline personality disorder (BPD), the demand for it exceeds available …

Objective To examine the safety, effectiveness, and cost effectiveness of long acting insulin
for type 1 diabetes. Design Systematic review and network meta-analysis. Data sources …

There is growing interest globally in using real-world data (RWD) and real-world evidence (RWE)
for health technology assessment (HTA). Optimal collection, analysis, and use of RWD/…

Background Complex wounds present a substantial economic burden on healthcare systems,
costing billions of dollars annually in North America alone. The prevalence of complex …

Background. Real-world evidence can be a valuable tool when clinical trial data are incomplete
or uncertain. Bevacizumab was adopted as first-line therapy for metastatic colorectal …