Background: The use of proton pump inhibitors has been associated with an increased risk
of hip fracture. We sought to further explore the relation between duration of exposure to …

BACKGROUNDS & AIMS: Recent studies have shown an association between proton-pump
inhibitor use (PPI) and hip fracture. The mechanism by which PPI use promotes the …

Objective: We aimed to compare survival in the multiple sclerosis (MS) population with a
matched cohort from the general population, and to evaluate the association of comorbidity with …

Objective: We aimed to compare the incidence and prevalence of psychiatric comorbidity in
the multiple sclerosis (MS) population and in controls matched for age, sex, and geographic …

Background While mental comorbidity is considered common in multiple sclerosis (MS), its
impact is poorly defined; methods are needed to support studies of mental comorbidity. We …

Background: Despite the importance of comorbidity in multiple sclerosis (MS), methods for
comorbidity assessment in MS are poorly developed. Objective: We validated and applied …

Background & Aims: There are numerous gastroprotective strategies recommended for
reducing the risk of upper gastrointestinal (GI) complications in long-term users of nonsteroidal …

OBJECTIVES: The use of the common antidepressant class of serotonin-specific reuptake
inhibitors (SSRIs) is associated with an increased risk of upper gastrointestinal bleeding (UGIB…

Objective: Comorbidities are common in multiple sclerosis (MS) and adversely affect health
outcomes. However, the effect of comorbidity on treatment decisions in MS remains unknown…

METHODS We used a Canadian provincial administrative database to capture all PPI
prescriptions between 1996 and 2004. A person was defined as a high-intensity user if he used …