Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma
Follicular lymphoma is an incurable malignancy 1 , with transformation to an aggressive
subtype representing a critical event during disease progression. Here we performed whole-…
subtype representing a critical event during disease progression. Here we performed whole-…
T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production
…, F McClanahan, R Fatah, S Iqbal… - Blood, The Journal …, 2013 - ashpublications.org
T-cell exhaustion, originally described in chronic viral infections, was recently reported in
solid and hematologic cancers. It is not defined whether exhaustion contributes to T-cell …
solid and hematologic cancers. It is not defined whether exhaustion contributes to T-cell …
EZH2 mutations are frequent and represent an early event in follicular lymphoma
…, A Clear, S Montoto, J Matthews, S Iqbal… - Blood, The Journal …, 2013 - ashpublications.org
Gain of function mutations in the H3K27 methyltransferase EZH2 represent a promising
therapeutic target in germinal center lymphomas. In this study, we assessed the frequency and …
therapeutic target in germinal center lymphomas. In this study, we assessed the frequency and …
Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma
…, J Richter, SH Bernhart, A Efeyan, S Iqbal… - Nature …, 2016 - nature.com
Follicular lymphoma is an incurable B cell malignancy 1 characterized by the t(14;18)
translocation and mutations affecting the epigenome 2 , 3 . Although frequent gene mutations in …
translocation and mutations affecting the epigenome 2 , 3 . Although frequent gene mutations in …
Disease evolution and outcomes in familial AML with germline CEBPA mutations
…, B Schlegelberger, E Wozniak, S Iqbal… - Blood, The Journal …, 2015 - ashpublications.org
In-depth molecular investigation of familial leukemia has been limited by the rarity of
recognized cases. This study examines the genetic events initiating leukemia and details the …
recognized cases. This study examines the genetic events initiating leukemia and details the …
Defining characteristics of classical Hodgkin lymphoma microenvironment T-helper cells
P Greaves, A Clear, A Owen, S Iqbal… - Blood, The Journal …, 2013 - ashpublications.org
… Sameena Iqbal, Sameena Iqbal … Paul Greaves, Andrew Clear, Andrew Owen, Sameena
Iqbal, Abigail Lee, Janet Matthews, Andrew Wilson, Maria Calaminici, John G. Gribben; Defining …
Iqbal, Abigail Lee, Janet Matthews, Andrew Wilson, Maria Calaminici, John G. Gribben; Defining …
Renal failure after cardiac surgery: timing of cardiac catheterization and other perioperative risk factors
D Del Duca, S Iqbal, E Rahme, P Goldberg… - The Annals of thoracic …, 2007 - Elsevier
BACKGROUND: The incidence of acute renal failure after cardiac surgery remains high, and
the ability to predict renal failure using well-defined baseline risk factors is important. The …
the ability to predict renal failure using well-defined baseline risk factors is important. The …
Transformation of follicular lymphoma to diffuse large B-cell lymphoma may occur by divergent evolution from a common progenitor cell or by direct evolution from the …
E Carlotti, D Wrench, J Matthews, S Iqbal… - Blood, The Journal …, 2009 - ashpublications.org
To investigate the cell of origin linking follicular (FL) and transformed (t-FL) lymphomas, we
analyzed the somatic hypermutation (SHM) pattern of the variable region of the …
analyzed the somatic hypermutation (SHM) pattern of the variable region of the …
P110α-mediated constitutive PI3K signaling limits the efficacy of p110δ-selective inhibition in mantle cell lymphoma, particularly with multiple relapse
…, M Calaminici, J Matthews, S Iqbal… - Blood, The Journal …, 2013 - ashpublications.org
Phosphoinositide-3 kinase (PI3K) pathway activation contributes to mantle cell lymphoma (MCL)
pathogenesis, but early-phase studies of the PI3K p110δ inhibitor GS-1101 have …
pathogenesis, but early-phase studies of the PI3K p110δ inhibitor GS-1101 have …
[HTML][HTML] Impact of a specialized multidisciplinary tracheostomy team on tracheostomy care in critically ill patients
C de Mestral, S Iqbal, N Fong, J LeBlanc… - Canadian Journal of …, 2011 - ncbi.nlm.nih.gov
Background A multidisciplinary tracheostomy team was created in 2005 to follow critically ill
patients who had undergone a tracheostomy until their discharge from hospital. Composed …
patients who had undergone a tracheostomy until their discharge from hospital. Composed …
