We present the largest exome sequencing study of autism spectrum disorder (ASD) to date (n
= 35,584 total samples, 11,986 with ASD). Using an enhanced analytical framework to …

In the interest of more systematically documenting the early signs of autism, and of testing
specific hypotheses regarding their underlying neurodevelopmental substrates, we have …

The genetic architecture of autism spectrum disorder involves the interplay of common and
rare variants and their impact on hundreds of genes. Using exome sequencing, here we …

Background Co-occurring mental health or psychiatric conditions are common in autism,
impairing quality of life. Reported prevalences of co-occurring mental health or psychiatric …

The objective of this paper is to present data from the Ontario Child Health Study on the
prevalence of attention deficit disorder with hyperactivity (ADDH). The overall prevalence of …

Structural variation (copy number variation [CNV] including deletion and duplication,
translocation, inversion) of chromosomes has been identified in some individuals with autism …

• We studied the six-month prevalence of four child psychiatric disorders (conduct disorder,
hyperactivity, emotional disorder, and somatization) and patterns of service utilization for …

The objective of this study was to report on the prevalence and correlates of anxiety and
mood problems among 9- to 14- year-old children with Asperger syndrome (AS) and high-…

Rare copy-number variation (CNV) is an important source of risk for autism spectrum
disorders (ASDs). We analyzed 2,446 ASD-affected families and confirmed an excess of genic …

Chronic childhood illness, disability, and psychosocial problems are receiving major attention
in current pediatric care. Much of the evidence associating chronic physical problems and …