A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity
Obesity is a serious international health problem that increases the risk of several common
diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide …
diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide …
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
…, NJ Timpson, T Tuomi, J Tuomilehto, M Walker… - Nature …, 2008 - nature.com
Genome-wide association (GWA) studies have identified multiple loci at which common variants
modestly but reproducibly influence risk of type 2 diabetes (T2D) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , …
modestly but reproducibly influence risk of type 2 diabetes (T2D) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , …
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
The molecular mechanisms involved in the development of type 2 diabetes are poorly
understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 …
understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 …
Antimicrobial resistance in ESKAPE pathogens
Antimicrobial-resistant ESKAPE ( Enterococcus faecium , Staphylococcus aureus , Klebsiella
pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa , and Enterobacter …
pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa , and Enterobacter …
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D)
and 38,987 controls of European descent and following up previously unidentified meta-…
and 38,987 controls of European descent and following up previously unidentified meta-…
[HTML][HTML] A structural variation reference for medical and population genetics
…, A O'Donnell-Luria, A Baumann, R Munshi, M Walker… - Nature, 2020 - nature.com
Structural variants (SVs) rearrange large segments of DNA 1 and can have profound
consequences in evolution and human disease 2 , 3 . As national biobanks, disease-association …
consequences in evolution and human disease 2 , 3 . As national biobanks, disease-association …
Teenage pregnancy and adverse birth outcomes: a large population based retrospective cohort study
…, K Demissie, GG Rhoads, M Walker - International journal …, 2007 - academic.oup.com
Background Whether the association between teenage pregnancy and adverse birth
outcomes could be explained by deleterious social environment, inadequate prenatal care, or …
outcomes could be explained by deleterious social environment, inadequate prenatal care, or …
Large-scale association studies of variants in genes encoding the pancreatic β-cell KATP channel subunits Kir6. 2 (KCNJ11) and SUR1 (ABCC8) confirm that the …
The genes ABCC8 and KCNJ11, which encode the subunits sulfonylurea receptor 1 (SUR1)
and inwardly rectifying potassium channel (Kir6.2) of the β-cell ATP-sensitive potassium (K …
and inwardly rectifying potassium channel (Kir6.2) of the β-cell ATP-sensitive potassium (K …
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
S Nejentsev, JMM Howson, NM Walker, J Szeszko… - Nature, 2007 - nature.com
The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility
to more common diseases than any other region of the human genome, including almost …
to more common diseases than any other region of the human genome, including almost …
Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer
…, T Nelson, O Chipashvili, T Hagan, M Walker… - Science, 2017 - science.org
Colorectal cancers comprise a complex mixture of malignant cells, nontransformed cells, and
microorganisms. Fusobacterium nucleatum is among the most prevalent bacterial species …
microorganisms. Fusobacterium nucleatum is among the most prevalent bacterial species …
