The statins as anticancer agents

KKW Chan, AM Oza, LL Siu - Clinical cancer research, 2003 - AACR
3-Hydroxy-3-methylgutaryl CoA reductase inhibitors, commonly referred to as the statins,
have proven therapeutic and preventative effects in cardiovascular diseases. Recently, there …

Assessment of Food and Drug Administration–and European Medicines Agency–approved systemic oncology therapies and clinically meaningful improvements in …

…, R Saluja, L Everest, A Parmar, KKW Chan - JAMA network …, 2021 - jamanetwork.com
Importance For patients with cancer treated with palliative intent, quality of life (QOL) is a
critical aspect of treatment decision-making, alongside survival. However, regulatory approval …

Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy

…, JE Clarkson, M Macluskey, KKW Chan… - Cochrane Database …, 2011 - cochranelibrary.com
Background Oral cavity and oropharyngeal cancers are frequently described as part of a
group of oral cancers or head and neck cancer. Treatment of oral cavity cancer is generally …

Chemotherapy-induced cardiotoxicity: detection, prevention, and management

J Truong, AT Yan, G Cramarossa, KKW Chan - Canadian Journal of …, 2014 - Elsevier
Chemotherapy-induced cardiotoxicity is a major cause of morbidity and mortality in cancer
survivors. It might manifest as arrhythmia, hypertension, myocardial ischemia, …

Neoadjuvant treatments for locally advanced, resectable esophageal cancer: a network meta‐analysis

KKW Chan, R Saluja, K Delos Santos… - … journal of cancer, 2018 - Wiley Online Library
The relative survival benefits and postoperative mortality among the different types of neoadjuvant
treatments (such as chemotherapy only, radiotherapy only or chemoradiotherapy) for …

Cost effectiveness of hepatocellular carcinoma surveillance after a sustained virologic response to therapy in patients with hepatitis C virus infection and advanced …

…, SP Cleary, HLA Janssen, KKW Chan… - Clinical …, 2019 - Elsevier
Background & Aims Hepatitis C virus (HCV)-related cirrhosis increases the risk for hepatocellular
carcinoma (HCC). After a sustained virologic response (SVR) to anti-HCV therapy, the …

The temporal risk of heart failure associated with adjuvant trastuzumab in breast cancer patients: a population study

…, S Gavura, K Lien, KKW Chan - Journal of the …, 2016 - academic.oup.com
Background: The late cardiac effect of adjuvant trastuzumab and its potential interaction
with anthracycline have not been well-studied on a population level. Methods: In this …

Exploiting social interactions in mobile systems

AG Miklas, KK Gollu, KKW Chan, S Saroiu… - International Conference …, 2007 - Springer
The popularity of handheld devices has created a flurry of research activity into new
protocols and applications that can handle and exploit the defining characteristic of this new …

The economic burden of cancer care in Canada: a population-based cost study

…, MD Krahn, N Mittmann, JS Hoch, KKW Chan… - … Open Access Journal, 2018 - cmajopen.ca
Background: Resource and cost issues are a growing concern in health care. Thus, it is
important to have an accurate estimate of the economic burden of care. Previous work has …

[HTML][HTML] Chemoradiotherapy regimens for locoregionally advanced nasopharyngeal carcinoma: a Bayesian network meta-analysis

M Yan, A Kumachev, LL Siu, KKW Chan - European Journal of Cancer, 2015 - Elsevier
Background Concurrent chemoradiotherapy followed by adjuvant chemotherapy (CRT-A) is
often the regimen of choice in locoregionally advanced nasopharyngeal carcinoma (NPC). …