Hypertension Canada provides annually updated, evidence-based guidelines for the diagnosis,
assessment, prevention, and treatment of hypertension in adults and children. This year, …

Hypertension Canada’s 2020 guidelines for the prevention, diagnosis, risk assessment, and
treatment of hypertension in adults and children provide comprehensive, evidence-based …

Large-scale genetic studies are highly dependent on efficient and scalable multiplex SNP
assays. In this study, we report the development of Molecular Inversion Probe technology with …

CRISPR/Cas9 derived from the bacterial adaptive immunity pathway is a powerful tool for
genome editing, but the safety profiles of in vivo delivered Cas9 (including host immune …

Viral glycoproteins mediate entry by pH-activated or receptor-engaged activation and exist
in metastable pre-fusogenic states that may be stabilized by directed rational design. As …

Objective To use human cartilage samples and a mouse model of osteoarthritis (OA) to
determine whether extracellular superoxide dismutase (EC‐SOD) is a constituent of cartilage …

Although intramuscular (im) administration is the most commonly used route for licensed
vaccines, subcutaneous (sc) delivery is being explored for several new vaccines under …

The elicitation of broadly neutralizing antibodies (bNAbs) against the HIV-1 envelope
glycoprotein (Env) trimer remains a major vaccine challenge. Most cross-conserved protein …

The structure of BG505 gp140 SOSIP, a soluble mimic of the native HIV-1 envelope
glycoprotein (Env), marks the beginning of new era in Env structure-based immunogen design. …

The development of soluble envelope glycoprotein (Env) mimetics displaying ordered trimeric
symmetry has ushered in a new era in HIV-1 vaccination. The recently reported native, …