Objective: To update and expand the 2013 Clinical Practice Guidelines for the Management
of Pain, Agitation, and Delirium in Adult Patients in the ICU. Design:

Background Current management practices and outcomes in weaning from invasive
mechanical ventilation are poorly understood. We aimed to describe the epidemiology, …

… RN, PhD, FCCM, FAAN 17 ; van den Boogaard, Mark RN, PhD 18 ; Bosma, Karen J. MD
19 ; Brummel, Nathaniel E. MD, MSCI 20 ; Chanques, Gerald MD, PhD 21,22 ; Denehy …

Objectives: Coronavirus disease 2019 is caused by the novel severe acute respiratory syndrome
coronavirus 2 virus. Patients admitted to the ICU suffer from microvascular thrombosis, …

BACKGROUND: Although electronic cigarettes (e-cigarettes) were initially marketed as a
potential smoking-cessation aid and a safer alternative to smoking, the long-term health effect …

Objectives: Numerous risk factors for sleep disruption in critically ill adults have been described.
We performed a systematic review of all risk factors associated with sleep disruption in …

The acute respiratory distress syndrome (ARDS) arises from direct and indirect injury to the
lungs and results in a life-threatening form of respiratory failure in a heterogeneous, critically …

Background: Sleep and circadian disruption (SCD) is common and severe in the ICU. On
the basis of rigorous evidence in non-ICU populations and emerging evidence in ICU …

Abstract Treatment of respiratory failure has improved dramatically since the polio epidemic
in the 1950s with the use of invasive techniques for respiratory support: mechanical …

… Bosma has received honourarium for lectures and travel reimbursements from Covidien.
Dr. Bosma’s institution has received grant support from Covidien for Dr. Bosma’s research …