The evolutionary processes that drive universal therapeutic resistance in adult patients with
diffuse glioma remain unclear 1 , 2 . Here we analysed temporally separated DNA-…

Meningiomas are the most common primary intracranial tumour in adults 1 . Patients with
symptoms are generally treated with surgery as there are no effective medical therapies. The …

Definitive diagnosis of intracranial tumors relies on tissue specimens obtained by invasive
surgery. Noninvasive diagnostic approaches provide an opportunity to avoid surgery and …

Smoothened (SMO) inhibitors recently entered clinical trials for sonic-hedgehog-driven
medulloblastoma (SHH-MB). Clinical response is highly variable. To understand the mechanism(…

Recent advances in genomic technology have led to a better understanding of key molecular
alterations that underlie glioblastoma (GBM). The current WHO-based classification of …

Glioblastomas are the most common form of malignant primary brain tumor and an important
cause of morbidity and mortality. In recent years there have been important advances in …

The factors driving therapy resistance in diffuse glioma remain poorly understood. To
identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA …

Glioblastoma (GBM) is the most common and lethal primary brain tumor. Over the past few
years tremendous genomic and proteomic characterization along with robust animal models …

A defining hallmark of glioblastoma is altered tumor metabolism. The metabolic shift
towards aerobic glycolysis with reprogramming of mitochondrial oxidative phosphorylation, …

Background Sporadic arteriovenous malformations of the brain, which are morphologically
abnormal connections between arteries and veins in the brain vasculature, are a leading …