Transcription factors (TFs) and their specific interactions with targets are crucial for specifying
gene-expression programs. To gain insights into the transcriptional regulatory networks in …

Both genome-wide genetic and epigenetic alterations are fundamentally important for the
development of cancers, but the interdependence of these aberrations is poorly understood. …

ABSTRACT Machine learning offers the potential for effective and efficient classification of
remotely sensed imagery. The strengths of machine learning include the capacity to handle …

Background The efficacy and effectiveness of the quadrivalent human papillomavirus (HPV)
vaccine in preventing high-grade cervical lesions have been shown. However, data to …

The paper aims to comprehensively analyze key issues of current land use in China. It
identifies the major land-use problems when China is undergoing rapid urbanization. Then, the …

Cyclophilin D (CypD, encoded by Ppif) is an integral part of the mitochondrial permeability
transition pore, whose opening leads to cell death. Here we show that interaction of CypD …

OBJECTIVE: To report contemporary estimates of the prevalence of knee-related osteoarthritis
(OA) outcomes in African Americans and Caucasians aged > or = 45 years. METHODS: …

Driven by the emergence of new compute-intensive applications and the vision of the Internet
of Things (IoT), it is foreseen that the emerging 5G network will face an unprecedented …

Here we develop an option pricing method for European options based on the Fourier-cosine
series and call it the COS method. The key insight is in the close relation of the …

Big data has generated strong interest in various scientific and engineering domains over
the last few years. Despite many advantages and applications, there are many challenges in …