Although the Abelson (Abl) tyrosine kinase inhibitor imatinib mesylate has improved the
treatment of breakpoint cluster region–Abl (Bcr-Abl)–positive leukemia, resistance is often …

Mutations of CCAAT/enhancer–binding protein alpha (CEBPAmu) are found in 10% to 15%
of de novo acute myeloid leukemia (AML) cases. Double-mutated CEBPA (CEBPAdm) is …

In the opinion of the European LeukemiaNet (ELN), nucleophosmin member 1 gene
mutation (NPM1 mut)–positive acute myeloid leukemia (AML) with an fms-like kinase 3-internal …

RNA interference (RNAi) is a phenomenon of sequence-specific gene silencing in
mammalian cells and its discovery has lead to its wide application as a powerful tool in post-genomic …

Liver metastasis is one of the most important prognostic factors in lung cancer patients.
However, current therapies are not sufficient. RNA interference provides us a powerful and …

Purpose: β-catenin is the downstream effector of the Wnt signaling pathway, and it regulates
cell proliferation. β-catenin overexpression correlates positively with prognosis in several …

We evaluated the mechanism of recognition of myeloma cells by γδT cells. The expanded
γδT cells killed RPMI8226 and U266 myeloma cells in a γδT-cell dose-dependent manner. …

Central nervous system (CNS) relapse accompanying the prolonged administration of imatinib
mesylate has recently become apparent as an impediment to the therapy of Philadelphia …

The effect of ABT‐737, a BH3‐mimicking inhibitor for anti‐apoptotic Bcl‐2 and Bcl‐X L , but
not Mcl‐1, against Bcr‐Abl‐positive (Bcr‐Abl + ) leukaemic cells was examined. ABT‐737 …

Background Clinical manifestations and optimal management strategies in patients with
splanchnic vein thrombosis (SVT) are not well characterized. Methods We conducted a …