Comprehensive knowledge of the brain’s wiring diagram is fundamental for understanding
how the nervous system processes information at both local and global scales. However, with …

The mammalian cortex is a laminar structure containing many areas and cell types that are
densely interconnected in complex ways, and for which generalizable principles of …

Significant advances in circuit-level analyses of the brain require tools that allow for labeling,
modulation of gene expression, and monitoring and manipulation of cellular activity in …

Understanding how >30 types of retinal ganglion cells (RGCs) in the mouse retina each
contribute to visual processing in the brain will require more tools that label and manipulate …

The claustrum (CLA) is a conspicuous subcortical structure interconnected with cortical and
subcortical regions. Its regional anatomy and cell-type-specific connections in the mouse …

Brain circuits comprise vast numbers of interconnected neurons with diverse molecular,
anatomical and physiological properties. To allow targeting of individual neurons for structural …

Identification of structural connections between neurons is a prerequisite to understanding
brain function. Here we developed a pipeline to systematically map brain-wide monosynaptic …

The mammalian cortex is a laminar structure composed of many cell types densely interconnected
in complex ways. Recent systematic efforts to map the mouse mesoscale connectome …

As an anterograde neuronal tracer, recombinant adeno‐associated virus (AAV) has distinct
advantages over the widely used biotinylated dextran amine (BDA). However, the sensitivity …

Single-cell characterization and perturbation of neurons provides knowledge critical to
addressing fundamental neuroscience questions including the structure–function relationship …