Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …

Stratification of women according to their risk of breast cancer based on polygenic risk scores
(PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, …

Objectives Long-term night work has been suggested as a risk factor for breast cancer;
however, additional studies with more comprehensive methods of exposure assessment to …

Night shift work has been suspected to increase breast cancer risk but epidemiological studies
have been inconsistent due to heterogeneous assessment of exposure to night work. To …

Genome-wide association studies have identified breast cancer risk variants in over 150
genomic regions, but the mechanisms underlying risk remain largely unknown. These regions …

Background: Shift work has been identified as a risk factor for several cancer sites in recent
years, with melatonin as a potential intermediate on the proposed causal pathway. This study …

Long-term, night shiftwork has been identified as a potential carcinogenic risk factor. It is
hypothesized that increased light at night exposure during shiftwork reduces melatonin …

… Anne Grundy was supported by a postdoctoral fellowship from Cancer Care Ontario. The
funders had no role in study design, data collection and analysis, decision to publish, or …

… This work is part of a doctoral thesis by Anne Grundy who was supported by a Canadian
Institutes of Health Research Doctoral Research Award. Angela Brooks-Wilson is a Senior …

Methods: Using multivariate polytomous logistic regression, we investigated the associations
between shift work (evening/night, rotating and other shift schedules) and overweight and …