Antimicrobial drug treatment of travelers' diarrhea is known to increase the risk for colonization with extended-spectrum β-lactamase-producing Enterobacteriaceae. Among 288 travelers with travelers' diarrhea, the colonization rate without medications was 21%. For treatment with loperamide only, the rate was 20%; with antimicrobial drugs alone, 40%; and with loperamide and antimicrobial drugs, 71%.
Keywords: AMD; ESBL; antibiotic resistance; antibiotics; antidiarrheal; antimicrobial drugs; antimicrobial resistance; diarrhea; extended-spectrum beta-lactamase–producing Enterobacteriaceae; loperamide; travel; travel health; travel medicine; travelers’ diarrhea.