Preventing Diabetic Ketoacidosis

Craig A Jefferies; Meranda Nakhla; José G B Derraik; Alistair J Gunn; Denis Daneman; Wayne S Cutfield

doi:10.1016/j.pcl.2015.04.002

Preventing Diabetic Ketoacidosis

Pediatr Clin North Am. 2015 Aug;62(4):857-71. doi: 10.1016/j.pcl.2015.04.002. Epub 2015 May 30.

Authors

Craig A Jefferies¹, Meranda Nakhla², José G B Derraik³, Alistair J Gunn⁴, Denis Daneman⁵, Wayne S Cutfield⁶

Affiliations

¹ Paediatric Endocrinology Service, Starship Children's Hospital, Auckland District Health Board, 2 Park Road, Auckland, 1023, New Zealand; Liggins Institute, University of Auckland, 85 Park Road, Auckland, 1023, New Zealand. Electronic address: CraigJ@adhb.govt.nz.
² Department of Paediatrics, Montreal Children's Hospital, McGill University, 2300 Tupper Street, H3H 1P3, Montreal, Canada.
³ Liggins Institute, University of Auckland, 85 Park Road, Auckland, 1023, New Zealand.
⁴ Paediatric Endocrinology Service, Starship Children's Hospital, Auckland District Health Board, 2 Park Road, Auckland, 1023, New Zealand; Department of Physiology, University of Auckland, 85 Park Road, Auckland, 1023, New Zealand.
⁵ Department of Pediatrics, The Hospital for Sick Children, University of Toronto, 555 University Avenue, M5G 1X8, Toronto, Canada.
⁶ Paediatric Endocrinology Service, Starship Children's Hospital, Auckland District Health Board, 2 Park Road, Auckland, 1023, New Zealand; Liggins Institute, University of Auckland, 85 Park Road, Auckland, 1023, New Zealand.

PMID: 26210621
DOI: 10.1016/j.pcl.2015.04.002

Abstract

Diabetic ketoacidosis (DKA) is a major cause of morbidity and mortality in children with type 1 diabetes mellitus (T1DM). This article examines the factors associated with DKA in children with T1DM, both at first presentation and in recurrent cases. The challenge for future research is to find effective ways to improve primary care physician and general community awareness of T1DM to reduce DKA at presentation and develop practical, cost-effective programs to reduce recurrent DKA.

Keywords: Diabetic ketoacidosis; Education; Girls; Noncompliance; Prevention; Recurrent; Type 1 diabetes mellitus.

Publication types

Review

MeSH terms

Adolescent
Age Factors
Child
Child, Preschool
Diabetes Mellitus, Type 1 / complications*
Diabetic Ketoacidosis / complications
Diabetic Ketoacidosis / etiology*
Diabetic Ketoacidosis / prevention & control*
Female
Humans
Infant
Male
Risk Factors
Sex Factors