Ticks are capable of transmitting numerous pathogens to both humans and their pets. The risks of tick-borne disease risks vary geographically and are determined by the climate, environment, the presence of rodents and other mammal reservoirs, and the species of ticks parasitizing wild and domestic animals. Zoonoses such as Lyme borreliosis, tularemia, and tick-borne rickettsioses can emerge in previously nonendemic areas when circumstances favorable to their maintenance and transmission arise. Tick-borne zoonosis can be prevented by implementation and adoption of an integrated program to reduce the likelihood of tick bites on pets and their owners.