Epidemiologic studies of air pollution require accurate exposure assessments at unmonitored locations in order to minimize exposure misclassification. One approach gaining considerable interest is the land-use regression (LUR) model. Generally, the LUR model has been utilized to characterize air pollution exposure and health effects for individuals residing within urban areas. The objective of this article is to briefly summarize the history and application of LUR models to date outlining similarities and differences of the variables included in the model, model development, and model validation. There were 6 studies available for a total of 12 LUR models. Our findings indicated that among these studies, the four primary classes of variables used were road type, traffic count, elevation, and land cover. Of these four, traffic count was generally the most important. The model R2 explaining the variability in the exposure estimates for these LUR models ranged from .54 to .81. The number of air sampling sites generating the exposure estimates, however, was not correlated with the model R2 suggesting that the locations of the sampling sites may be of greater importance than the total number of sites. The primary conclusion of this study is that LUR models are an important tool for integrating traffic and geographic information to characterize variability in exposures.