Objective: We used receiver operating characteristic (ROC) analysis to compare two methods of evaluating observer performance in detecting an abnormality on chest radiographs. In the first method, the abnormality in question, rib fracture, was one of five investigated, and it was the only one of interest in the second.
Materials and methods: Eight experienced observers viewed 117 posteroanterior chest radiographs in two interpretation modes. Fifty-four of these images depicted rib fractures that had been rated as subtle for detection. The likelihood of the presence of a rib fracture was rated as one of five abnormalities in question in one mode and the sole abnormality of interest in the other mode.
Results: Six of the observers performed better during the single-abnormality mode, one performed equally well in both modes, and one performed better during the multiple-abnormality mode. The average area under the ROC curves (A(z)) was 0.73 +/- 0.07 for the multiple-abnormality mode and 0.80 +/- 0.04 for the single-abnormality mode. The results were significantly different (p < 0.05).
Conclusion: Study methodology can significantly affect the results in ROC studies, particularly for abnormalities that may not be perceived as primary or important. The order in which abnormalities appear on a checklist report form may be important.