Research paperPrevotella and Klebsiella proportions in fecal microbial communities are potential characteristic parameters for patients with major depressive disorder
Section snippets
Instruction
Major depressive disorder is one of the major and common psychiatric disorders with high rates of self-harm and suicide attempts. The real causes and pathogenesis of major depressive disorder are not well understood (Hegerl et al., 2013). A diverse contribution of genetic, neurochemical and environmental factors are involved in the onset and progression of depression (Wang et al., 2015). The bidirectional interactions between the central nervous system, the enteric nervous system, and the
Ethics statement
The institutional Review Board (IRB) at Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine approved the study. Patients who expressed interest in joining this study were introduced the details and signed the written consent forms.
Subject recruitment and study procedure
Sixty MDD patients were recruited in this study, and another 60 people were selected as control. The basic enrollment criteria of the patient recruitment are: (1) age 20–85 years; (2) no usage of any type of antibiotic, antifungal
Subject characteristics
Ten MDD patients performed the study procedure completely, that means total 30 patients’ stool specimen were collected for metagenomic sequencing in this study. Another 10 control stool samples were randomly selected from the 60 subjects. The common characteristics of 10 MDD patients and control subjects were shown in Table 1.
Major bacterial organism in subjects of MDD and control groups
All MDD patients received the regular treatment in this study. The major bacterial organism in subjects of MDD (3 visits) and control groups were calculated in phylum
Discussion
Intestinal microbiota constitutes a symbiotic ecosystem that keeps homeostatic balance inside the human body. However, this equilibrium can be disrupted by pathological conditions interfering with intestinal physiology (Kang et al., 2013). There are complicated correlation between the components of gut flora and several diseases, includes infectious diseases and non infectious disease. However, the pattern of gut flora is affected by many factors such as the diet, race, geography, local
Conclusions
The proportion changes of prevotella and klebsiella in fecal flora could be useful parameters for the laboratory diagnosis and treatment evaluation in MDD patients.
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Ping Lin and Bingyu Ding share first authorship, Yongzhang Zhu and Qingtian Li share last authorship.