Journal of the American Academy of Child & Adolescent Psychiatry
New ResearchBeyond Autism: A Baby Siblings Research Consortium Study of High-Risk Children at Three Years of Age
Section snippets
Participants
Participant data were obtained from nine member sites whose recruitment procedures and common assessment measures allowed for data pooling. Institutional review board approval was obtained to collect and analyze de-identified data from all sites. Infants were enrolled at a mean age of 8.04 months (SD = 4.00 months) and were administered complete clinical evaluations at a mean age of 37.10 months (SD = 2.32 months). All children with an ASD, that is, children who met both clinical judgment and
Preliminary Analyses
Descriptive Statistics. There were no group differences in race (white versus other) or sex (Table 1). There was a significant group difference for maternal education (X2 = 6.21, df = 1, p<.05), with a higher proportion of mothers in the LR group having college or graduate degrees. HR siblings were enrolled slightly later than children in the LR group (F1,830 = 36.92, p<.001) , and were more likely to have received module 1 rather than module 2 of the ADOS at outcome (χ2 = 10.65, df = 1, p<
Discussion
This is the first large-scale examination of ASD behavioral characteristics and developmental functioning in HR siblings without an ASD outcome. Objective, standardized assessments indicated that, as a group, HR siblings had slightly higher ASD severity scores, lower levels of verbal functioning, and slightly lower levels of nonverbal functioning than LR comparison children. A latent class analysis distinguished groups of HR and LR children with similar 3-year outcomes. Although HR siblings
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Autism Speaks provided funding for the creation of a Baby Siblings Research Consortium (BSRC) database and data analysis (G.S.Y.). Data collection was supported by the National Institutes of Health (NIH) grants MH068398 (S.O., S.J.R., G.S.Y.), NIH DC10290 (A.C.), NIH HD047417 (D.M.), NIH HD057284 (W.L.S., D.M.), NIH HD042541 (J.N.C.), HD052804 (K.D., L.J.C.), HD54979 (J.M.I.), NIH U54-MH066417 and MH059630 (R.J.L.), NIH U54-MH068172 (M.S., T.H.), and NIH HD043292 (W.L.S.); the United States–Israel Binational Science Foundation 94-66/3 and 97-00073 (M.S.); and the Canadian Institute for Health Research 62924 and 102665 (L.Z., S.B.).
Supplemental material cited in this article is available online.
Dr. Gregory S. Young served as the statistical expert for this research.
The authors thank Alycia Halladay, Ph.D., of Autism Speaks, for tremendous organization support, and Batya Elbaum, Ph.D., of the University of Miami, for editorial assistance.
Disclosure: Dr. Carter has received royalties from the Infant Toddler Social Emotional Assessment (ITSEA). Dr. Charman has received grant or research support from the UK Medical Research Council, the European Science Foundation, Autistica, Research Autism, the Autism Education Trust, and Autism Speaks. He has received royalties from Guilford Press and Sage. Dr. Constantino has received grant or research support from NIH, the National Institute of Child Health and Human Development, the National Institute of Mental Health, the Department of Health and Human Services, Autism Speaks, and the Centers for Disease Control and Prevention. He has received royalties for the authorship of assessment tools from Western Psychological Services (SRS). Dr. Rogers is the author of Early Start Denver Model for Young Children With Autism, published by Guilford Press, from which she has received royalties. Dr. Sigman is deceased. Drs. Messinger, Young, Ozonoff, Dobkins, Zwaigenbaum, Landa, Stone, Hutman, Carver, Bryson, Iverson, and Strauss report no biomedical financial interests or potential conflicts of interest.