Meeting paperPCOGS papersUtilization of noninvasive prenatal testing: impact on referrals for diagnostic testing
Section snippets
Materials and Methods
A retrospective cohort study using a natural experiment pre-NIPT and post-NIPT was conducted to compare a group of women referred to the Cedars-Sinai Prenatal Diagnosis Center for genetic counseling and prenatal testing from Jan. 1, 2010, through Dec. 31, 2011 (pre-NIPT) with women referred from Jan. 1, 2012, through Dec. 31, 2013 (post-NIPT). The primary outcome for the study was the difference in the number of women referred to our center for genetic counseling and prenatal diagnosis during
Results
During the pre-NIPT period, 3944 women were referred for counseling and testing. In the post-NIPT period, 2824 women were referred for counseling and testing. This represents a significant decrease in referrals of 28.4% (P = .001). A comparison between the study groups is shown in Table 1. There was a statistically significant decrease in the referrals for advanced maternal age (89.3% vs 79.4%; P = .001). No differences in referral rate were observed for follow-up of a positive first-trimester
Comment
Between the pre-NIPT and post-NIPT study periods, we observed a 28% decrease in the overall number of patients referred for genetic counseling and prenatal diagnosis. There was a statistically significant decrease in the referrals for advanced maternal age. We also found that there was a significant reduction in the number of patients who would not be candidates for NIPT due to the presence of multiple gestations, vanishing twin, and risk for either single gene disorders or unbalanced
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Cited by (0)
J.W. is a member of the advisory panel for Natera Inc, San Carlos, CA. The remaining authors report no conflict of interest.
Cite this article as: Williams J, Rad S, Beauchamp S, et al. Utilization of noninvasive prenatal testing: impact on referrals for diagnostic testing. Am J Obstet Gynecol 2015;213:102.e1-6.