Clinical InvestigationOutcomes, Health Policy, and Managed CareAltered health status and quality of life in South Asians with coronary artery disease
Section snippets
Data source
The Alberta Provincial Project for Outcomes Assessment in Coronary Heart Disease (APPROACH) is a prospective clinical data collection initiative capturing all patients undergoing cardiac catheterization and revascularization in the province of Alberta, Canada, since 1995. The registry contains detailed clinical information including patient's age; sex; ejection fraction; and the presence or absence of previous myocardial infarction, congestive heart failure, cerebrovascular disease, peripheral
Results
After excluding patients of Chinese descent, a total of 49,456 patients with established angiographic CAD (>50% stenosis) were identified from January 1995 to December 2006 (Figure 1). Of these, 2,168 patients were of SA decent, and 47,288 patients were of European ancestry. Because of deaths and refusal of consent, there were 1,612 eligible SA patients and 34,252 eligible European patients. Of these, patients who responded with 1-year SAQ results were included in our study, leaving 635 SA and
Discussion
Health-related QOL has been increasingly used as a measure of health-related outcome including major end points in large clinical trials. Consequently, there has been a shift in treatment of CAD focusing on not only enhanced survival but also on improvement of ischemic symptoms and overall functional levels.14, 15, 16 Using the easily accessible SAQ, a research tool whose effectiveness in documenting changes in HRQOL outcomes in patients with CAD is well established, we were able to show that
Disclosures
This work was supported by Approach, which has funded in 1995 by the Weston Foundation, with ongoing support from Merck Frosst Canada, Inc; Monsanto Canada, Inc, Searle Eli Lilly Canada, Inc; Guidant Corporation; Boston Scientific Ltd; Hoffmann-La Roche Ltd; Johnson & Johnson, Inc, Cordis; and the Province-Wide Services Committee of Alberta Health and Wellness.
Acknowledgements
We appreciate the assistance of the Calgary Health Region and the Capital Health Authority in supporting data entry by cardiac catheterization laboratory personnel. Alberta Provincial Project for Outcomes Assessment in Coronary Heart Disease receives support from industry sponsors. C.M.N. is supported by a New Investigators Award from Canadian Institute of Health Research and a Population Health Investigators Award from the Alberta Heritage Foundation for Medical Research.
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