Elsevier

The Lancet

Volume 344, Issue 8930, 22 October 1994, Pages 1120-1124
The Lancet

Articles
Lower socioeconomic status and shorter survival following HIV infection

https://doi.org/10.1016/S0140-6736(94)90631-9Get rights and content

Abstract

We studied the association between socioeconomic status and survival in a prospective study of 364 HIV-infected homosexual men who were recruited during 1982-84. The participants were divided by annual income; those earning above Canadian $10 000 (high-income; n=274) and those below $10 000 (low-income; n=90) at recruitment. The latter threshold closely approximated to the poverty level for this population. Low income men were significantly younger than high income men but the groups were similar with respect to baseline CD4 counts, subsequent use of anti-retrovirals and prophylaxis against Pneumocystis carinii pneumonia (PCP), and number of visits attended during follow-up. Subjects were followed for a median of 9·5 years (range 1·8-13·1). By Dec 31, 1993, there were 135 deaths yielding a cumulative mortality rate of mean 45% (SD 4·0) at 11·5 years. Men aged 30 or more at infection had poorer survival than those under 30 (mortality risk ratio 1·56; 95% Cl 1·09-2·24; p=0·015), and longer survival was significantly associated with a higher CD4 count at the earliest seropositive visit. The age-adjusted mortality risk ratio for low income men compared with high income men was significantly increased at 1·63 (95% Cl 1·11-2·40; p=0·013). The significant risk of death for low income men persisted despite adjustment for age at infection, CD4 count, use of zidovudine, dideoxyinosine, and dideoxycytidine, use of PCP prophylaxis, and year of infection. We cannot attribute our findings to income loss as a result of more rapid HIV progression because the same effect was present in people who provided income data before seroconversion. Similarly, our findings are not due to differential access to care because the study was done within the context of a universal health care system, and the two income groups received treatments equally. This finding is consistent with the association of lower socioeconomic status with increased morbidity and mortality observed within large populations and in other diseases.

References (31)

  • Mt Schechter et al.

    The Vancouver Lymphadenopathy-AIDS Study, 6: HIV seroconversion in a cohort of homosexual men

    Can Med Assoc J

    (1986)
  • Statistics Canada

    (1982-84)
  • Centers for Disease Control

    Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome

    MMWR CDC Surveill Summ

    (1987)
  • Aj Saah et al.

    Factors influencing survival after AIDS: report from the multicente AIDS cohort study (MACS)

    J Acquir Immune Defic Syndr

    (1994)
  • R. Rothenberg et al.

    Survival with the acquired immunodeficiency syndrome. Experience with 5833 cases in New York City

    N Engl J Med

    (1987)
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