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Pathogenesis of endometriosis: the role of genetics, inflammation and oxidative stress

  • General Gynecology
  • Published:
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Abstract

Introduction

Endometriosis is defined as the presence of endometrial tissue outside the uterine cavity.

Materials and Methods

The etiology of this multifactorial disease is still unresolved and an increasing number of studies suggest that genetic, hormonal, environmental, immunological and oxidative factors may all play an important role in the pathogenesis of this disorder.

Conclusions

In this literature review, inflammatory activity, oxidative stress as well as genetic abnormalities and mutations have been studied in an effort to identify factors predisposing to endometriosis.

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Authors and Affiliations

  1. 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, 6, Feidippidou Street, Ampelokipi, GR-11526, Athens, Greece

    A. Augoulea, M. Creatsa, N. Vrachnis & I. Lambrinoudaki

  2. Obstetric, Gynecological Unit and Research Center, Evgenideio Hospital, University of Athens, Athens, Greece

    A. Augoulea & N. Vrachnis

  3. 1st Department of Surgery, Laiko Hospital, University of Athens, Athens, Greece

    A. Alexandrou

Authors
  1. A. Augoulea
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  2. A. Alexandrou
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  3. M. Creatsa
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  4. N. Vrachnis
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  5. I. Lambrinoudaki
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Correspondence to A. Augoulea.

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Augoulea, A., Alexandrou, A., Creatsa, M. et al. Pathogenesis of endometriosis: the role of genetics, inflammation and oxidative stress. Arch Gynecol Obstet 286, 99–103 (2012). https://doi.org/10.1007/s00404-012-2357-8

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  • DOI: https://doi.org/10.1007/s00404-012-2357-8

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