Summary.
Twenty-two NIDDM patients completed an open randomized cross-over study comparing metformin and glibenclamide over 1 year.
The drugs had an equivalent effect on glycaemic control, but, in contrast to glibenclamide, metformin reduced body weight. Neither drug affected triglycerides, total-and LDL-cholesterol or C-peptide. Metformin caused a slight elevation of HDL-cholesterol (P < 0.05). No serious adverse effects were observed.
The results show that oral hypoglycaemic agents are not associated with undesirable effects on lipids and lipoproteins.
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Hermann, L.S., Karlsson, J.E. & Sjöstrand, Å. Prospective comparative study in NIDDM patients of metformin and glibenclamide with special reference to lipid profiles. Eur J Clin Pharmacol 41, 263–265 (1991). https://doi.org/10.1007/BF00315441
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DOI: https://doi.org/10.1007/BF00315441