Outcomes of patients admitted to hospital for acute COVID-19 during the Omicron wave by SARS-CoV-2 vaccination status
| Variable | Vaccination status* | p value | ||
|---|---|---|---|---|
| No. (%)† of all patients n = 441 | No. (%)† of unvaccinated patients n = 130 | No. (%)† of patients with ≥ 2 doses n = 242 | ||
| 28-day mortality | 42/433 (9.7) | 12/127 (9.4) | 19/237 (8.0) | 0.64 |
| In-hospital death | 63/441 (14.3) | 19/130 (14.6) | 30/242 (12.4) | 0.55 |
| Admitted to ICU | 121/441 (27.4) | 49/130 (37.7) | 57/242 (23.6) | 0.004 |
| Septic shock | 39/430 (9.1) | 11/125 (8.8) | 23/237 (9.7) | 0.78 |
| Acute respiratory distress syndrome | 66/437 (15.1) | 31/129 (24.0) | 25/239 (10.5) | < 0.001 |
| Acute kidney injury | 119/429 (27.7) | 32/129 (24.8) | 76/232 (32.8) | 0.11 |
| Acute cardiac injury | 18/418 (4.3) | 4/126 (3.2) | 12/226 (5.3) | 0.36 |
| Organ support while hospitalized | ||||
| Invasive mechanical ventilation | 61/441 (13.8) | 28/130 (21.5) | 26/242 (10.7) | 0.005 |
| RRT or dialysis | 30/439 (6.8) | 7/129 (5.4) | 20/241 (8.3) | 0.31 |
| Vasopressors | 70/440 (15.9) | 26/129 (20.2) | 34/242 (14.0) | 0.13 |
| Organ support during first 14 days | ||||
| Invasive mechanical ventilation | 53/439 (12.1) | 24/128 (18.8) | 22/242 (9.1) | 0.007 |
| RRT or dialysis | 23/436 (5.3) | 5/128 (3.9) | 15/239 (6.3) | 0.34 |
| Vasopressors | 62/437 (14.2) | 23/129 (17.8) | 29/239 (12.1) | 0.13 |
| DAF invasive mechanical ventilation, first 14 days | 0.04 | |||
| Mean ± SD | 12.5 ± 4.0 | 12.1 ± 4.3 | 12.9 ± 3.4 | – |
| Unknown, n | 18 | 10 | 6 | – |
| DAF RRT — first 14 days | – | – | – | 0.43 |
| Mean ± SD | 13.1 ± 3.2 | 13.4 ± 2.8 | 13.3 ± 2.9 | – |
| Unknown, n | 23 | 10 | 11 | – |
| DAF vasopressors, first 14 days | – | – | – | 0.24 |
| Mean ± SD | 12.6 ± 3.8 | 12.4 ± 3.9 | 12.9 ± 3.4 | – |
| Unknown, n | 20 | 9 | 9 | – |
| Hospital length of stay, decedents | – | – | – | 0.23 |
| n | 48 | 12 | 24 | – |
| Median (IQR) | 16.5 (9.5–35.5) | 32.5 (14.0–77.5) | 18.5 (10.5–33.5) | – |
| Range | (2.0–246.0) | (3.0–246.0) | (4.0–97.0) | – |
| Hospital length of stay, survivors | – | – | – | 0.01 |
| n | 378 | 111 | 212 | – |
| Median (IQR) | 8.0 (4.0–16.0) | 11.0 (5.0–18.0) | 7.0 (4.0–13.0) | – |
| Range | (1.0–143.0) | (2.0–143.0) | (1.0–110.0) | – |
| ICU length of stay, decedents | – | – | – | 0.18 |
| n | 37 | 12 | 17 | |
| Median (IQR) | 15.0 (10.0– 29.0) | 23.0 (14.0–66.5) | 16.0 (10.0–29.0) | – |
| Range | (0.0–246.0) | (4.0–246.0) | (1.0–84.0) | – |
| ICU length of stay, survivors | – | – | – | 0.73 |
| n | 77 | 36 | 35 | |
| Median (IQR) | 6.0 (3.0–12.0) | 6.5 (3.5–11.0) | 6.0 (3.0–13.0) | – |
| Range | (0.0–85.0) | (1.0–85.0) | (0.0–29.0) | – |
Note: DAF = days alive and free, ICU = intensive care unit, IQR = interquartile rage, RRT = renal replacement therapy, SD = standard deviation.
↵* Patients who received only a single dose of vaccine (n = 18) or with uncertain vaccination status (n = 51) were excluded from the stratified summary.
↵† Unless otherwise indicated.