Characteristics of patients undergoing same-day breast surgery in Ontario, Canada, during the study period, categorized by filling of opioid prescriptions within 7 days of surgery date (n = 84 369)*
| Variable | No. (%)† who filled opioid prescription, days 0–7 | No. (%)† who did not fill opioid prescription | No. (%)† of all patients | Standardized difference |
|---|---|---|---|---|
| Any opioid prescription filled up to 7 d after surgery | 60 620 | 23 749 | 84 369 | N/A |
| Sex | ||||
| Female | 59 627 (71.9) | 23 319 (28.1) | 82 946 (98.3) | 0.013 |
| Male | 993 (69.8) | 430 (30.2) | 1423 (1.7) | 0.013 |
| Age at surgery date, yr | ||||
| Median (IQR) | 58 (48–68) | 59 (48–69) | 58 (48–68) | 0.074 |
| Age, yr | ||||
| 18–29 | 3230 (71.0) | 1320 (29.0) | 4550 (5.4) | 0.01 |
| 30–39 | 4146 (71.3) | 1669 (28.7) | 5815 (6.9) | 0.007 |
| 40–49 | 10 158 (73.5) | 3656 (26.5) | 13 814 (16.4) | 0.037 |
| 50–59 | 15 411 (73.9) | 5429 (26.1) | 20 840 (24.7) | 0.06 |
| 60–69 | 14 992 (72.1) | 5793 (27.9) | 20 785 (24.6) | 0.008 |
| 70–79 | 9471 (69.8) | 4091 (30.2) | 13 562 (16.1) | 0.043 |
| ≥ 80 | 3212 (64.2) | 1791 (35.8) | 5003 (5.9) | 0.092 |
| Charlson Comorbidity Index score | ||||
| 0–1 | 55 764 (72.5) | 21 175 (27.5) | 76 939 (91.2) | 0.097 |
| ≥ 2 | 4856 (65.4) | 2574 (34.6) | 7430 (8.8) | 0.097 |
| Socioeconomic status (quintiles) | ||||
| 1 (lowest) | 10 490 (69.9) | 4509 (30.1) | 14 999 (17.8) | 0.044 |
| 2 | 11 932 (72.1) | 4626 (27.9) | 16 558 (19.6) | 0.005 |
| 3 | 12 265 (72.4) | 4665 (27.6) | 16 930 (20.1) | 0.015 |
| 4 | 12 599 (72.4) | 4809 (27.6) | 17 408 (20.6) | 0.013 |
| 5 (highest) | 13 334 (72.2) | 5140 (27.8) | 18 474 (21.9) | 0.009 |
| Location of residence | ||||
| Missing data | 80 (62.0) | 49 (38.0) | 129 (0.2) | 0.018 |
| Rural | 6519 (69.9) | 2808 (30.1) | 9327 (11.1) | 0.034 |
| Urban | 54 021 (72.1) | 20 892 (27.9) | 74 913 (88.8) | 0.036 |
| Hospital type | ||||
| Missing data | 1966 (65.0) | 1059 (35.0) | 3025 (3.6) | 0.063 |
| Community | 43 018 (74.3) | 14 852 (25.7) | 57 870 (68.6) | 0.18 |
| Pediatric | 54 (40.3) | 80 (59.7) | 134 (0.2) | 0.054 |
| Small | 299 (51.3) | 284 (48.7) | 583 (0.7) | 0.077 |
| Teaching | 15 283 (67.2) | 7474 (32.8) | 22 757 (27.0) | 0.139 |
| Breast cancer diagnosis | ||||
| No | 24 735 (67.0) | 12 172 (33.0) | 36 907 (43.7) | 0.211 |
| Yes | 35 885 (75.6) | 11 577 (24.4) | 47 462 (56.3) | 0.211 |
| Type of procedure | ||||
| Excision partial breast only ± axillary intervention | 51 855 (70.6) | 21 569 (29.4) | 73 424 (87.0) | 0.164 |
| Excision total breast ± axillary intervention | 3698 (79.8) | 938 (20.2) | 4636 (5.5) | 0.099 |
| Excision radical breast ± axillary intervention | 2175 (82.6) | 458 (17.4) | 2633 (3.1) | 0.101 |
| Bilateral surgery | 2892 (78.7) | 784 (21.3) | 3676 (4.4) | 0.075 |
| Patients filling additional opioid prescription(s) within 7 d of surgery | ||||
| 0 additional | 58 380 (100.0) | 0 | 58 380 (69.2) | 7.22 |
| 1 additional | 1948 (100.0) | 0 | 1948 (2.3) | 0.258 |
| 2 additional | 187 (100.0) | 0 | 187 (0.2) | 0.079 |
| ≥ 3 additional | 105 (100.0) | 0 | 105 (0.1) | 0.059 |
| NA | 0 | 23 749 (100.0) | 23 749 (28.1) | – |
| Year of surgery | ||||
| 2012 | 3959 (69.3) | 1751 (30.7) | 5710 (6.8) | 0.033 |
| 2013 | 8052 (73.1) | 2956 (26.9) | 11 008 (13.0) | 0.025 |
| 2014 | 8604 (73.7) | 3065 (26.3) | 11 669 (13.8) | 0.038 |
| 2015 | 8237 (74.1) | 2879 (25.9) | 11 116 (13.2) | 0.044 |
| 2016 | 8029 (74.5) | 2748 (25.5) | 10 777 (12.8) | 0.051 |
| 2017 | 7322 (71.4) | 2938 (28.6) | 10 260 (12.2) | 0.009 |
| 2018 | 6923 (70.0) | 2961 (30.0) | 9884 (11.7) | 0.032 |
| 2019 | 6774 (68.1) | 3171 (31.9) | 9945 (11.8) | 0.066 |
| 2020 | 2720 (68.0) | 1280 (32.0) | 4000 (4.7) | 0.042 |