Table 3:

Small-area variation analysis*

Outcome; statisticYearp value
2008/092009/102010/112011/122012/132013/142014/152015/16
Initiation of oral anticoagulant therapy
High stroke risk
 EQ24.010.34.76.23.210.03.72.80.04
 CV × 10023.320.015.622.118.622.521.318.50.5
 SCV × 100175.144.028.012.814.326.114.512.10.04
p value< 0.001< 0.001< 0.001< 0.001< 0.001< 0.001< 0.001< 0.001
Moderate stroke risk
 EQ16.95.87.58.37.76.93.914.90.7
 CV × 10031.031.530.228.025.931.429.230.80.5
 SCV × 10041.633.036.035.917.319.918.324.30.1
p value< 0.001< 0.001< 0.001< 0.001< 0.001< 0.001< 0.001< 0.001
Persistence with oral anticoagulant therapy
High stroke risk
 EQ19.84.09.16.912.84.85.72.30.2
 CV × 10027.524.923.221.523.626.626.919.20.5
 SCV × 10024.111.225.72.821.97.06.67.00.2
p value0.008< 0.0010.0040.09< 0.001< 0.001< 0.001< 0.001
Moderate stroke risk
 EQ16.214.28.47.017.917.18.523.20.5
 CV × 10045.047.239.540.138.144.753.541.81.00
 SCV × 100302.7329.0166.4424.2180.4196.4204.9254.71.00
p value< 0.001< 0.001< 0.001< 0.001< 0.001< 0.001< 0.001< 0.001
Ischemic stroke
EQ9.316.531.614.58.739.113.510.90.9
CV × 10049.553.048.748.262.561.857.752.20.7
SCV × 100< 1< 1< 1< 1< 1< 1< 1< 10.4
p value1.01.01.01.01.01.01.01.0
Major bleeding
EQ32.327.57.312.712.519.816.67.00.2
CV × 10051.051.338.549.555.544.747.041.80.4
SCV × 1006< 1< 110.97.1< 1< 1< 10.06
p value0.91.01.00.81.01.01.01.0
  • Note: CV = coefficient of variation, EQ = extremal quotient, SCV = systematic component of variation.

  • * Applied to age- and sex-standardized outcomes.

  • Mann–Kendall test for monotonic trends.

  • χ2 test for small-area variation in outcomes.