Indications for and yield of testing by Ontario MOH* testing criteria
| MOH testing criterion† | Test result; no. (%) of participants‡ | ||||
|---|---|---|---|---|---|
| All n = 15 986 | Positive n = 2033 | VUS n = 1175 | Negative§ n = 11 437 | ||
| Affected individuals | |||||
| At least 1 case of cancer | |||||
| MOH1 | Ashkenazi Jewish and breast cancer before age 50 yr or ovarian cancer at any age | 435 | 39 (9.0) | 24 (5.5) | 366 (84.1) |
| MOH2 | Breast cancer before age 35 yr | 1036 | 123 (11.9) | 108 (10.4) | 801 (77.3) |
| MOH4 | Invasive serous ovarian cancer at any age | 1327 | 195 (14.7) | 104 (7.8) | 1027 (77.4) |
| At least 2 cases of cancer on the same side of the family | |||||
| MOH5 | Breast cancer before age 60 yr and a first- or second-degree relative with ovarian cancer or male breast cancer | 1143 | 147 (12.9) | 115 (10.1) | 880 (77.0) |
| MOH6 | Breast and ovarian cancer in the same individual, or bilateral breast cancer with the first case before age 50 yr | 976 | 127 (13.0) | 86 (8.8) | 763 (78.1) |
| MOH7 | Two cases of breast cancer, both before age 50 yr, in first- or second-degree relatives | 1508 | 134 (8.9) | 160 (10.6) | 1210 (80.2) |
| MOH8 | Two cases of ovarian cancer, any age, in first- or second-degree relatives | 195 | 52 (26.7) | 17 (8.7) | 122 (62.6) |
| MOH9 | Ashkenazi Jewish and breast cancer at any age, and any family history of breast or ovarian cancer | 691 | 38 (5.5) | 29 (4.2) | 621 (89.9) |
| At least 3 cases of cancer on the same side of the family | |||||
| MOH10 | Three or more cases of breast or ovarian cancer at any age | 5293 | 355 (6.7) | 454 (8.6) | 4467 (84.4) |
| Unaffected individuals | |||||
| MOH11 | Relative of individual with known BRCA1 or BRCA2 mutation | 2394 | 860 (35.9) | 27 (1.1) | 237 (9.9) |
| MOH12 | Ashkenazi Jewish and first- or second-degree relative of individual with breast cancer before age 50 yr, or ovarian cancer at any age, or male breast cancer, or breast cancer at any age, with a positive family history of breast or ovarian cancer | 1277 | 92 (7.2) | 4 (0.3) | 1130 (88.5) |
| MOH13 | Pedigree strongly suggestive of hereditary breast or ovarian cancer (i.e., risk of carrying a mutation for the individual being tested is > 10%) | 2105 | 93 (4.4) | 175 (8.3) | 1830 (86.9) |
Note: MOH = Ministry of Health, VUS = variant of uncertain significance.
↵* At the time of the study, responsibility for health lay with the provincial Ministry of Health and Long-Term Care; this ministry has since been divided into 2 separate ministries.
↵† For any individual, multiple indications for testing could have been selected. The indication for testing was missing for 859 women. Criterion MOH3, for male breast cancer, is excluded from this table.
↵‡ Percentages are calculated across each row, with the denominator for each row being the value in the column headed “All.”
↵§ Of the 1341 women with a predictive negative result, 94.7% were tested under criterion MOH11; therefore, results are not shown for the predictive negative group.