Treatment and adverse drug reactions
| Variable | No. (%) of patients |
|---|---|
| Treatment | |
| Rapid rewarming | 13 (59) |
| Iloprost only | 9 (41) |
| Iloprost, alteplase and heparin | 4 (18) |
| Passive rewarming | 9 (41) |
| Iloprost only | 8 (36) |
| Iloprost, alteplase and heparin | 1 (4) |
| Treatment adjunct | |
| Topically administered aloe vera | 19 (86) |
| Scheduled orally administered ibuprofen | 22 (100) |
| No. of iloprost doses received | |
| 1 | 2 (9) |
| 3 | 3 (14) |
| 4 | 1 (5) |
| 5 | 16 (73) |
| Alteplase dosing (n = 5) | |
| 15 mg intravenously over 2 min, then 0.75 mg/kg (maximum 50 mg) over 30 min, then 0.5 mg/kg (maximum 35 mg) over 60 min | 1 (20) |
| 0.15 mg/kg over 15 min, then 0.15 mg/kg per hour intravenously for 6 h* | 4 (80) |
| Adverse drug reactions | |
| Iloprost | |
| Headache | 11 (50) |
| Flushing | 8 (36) |
| Tachycardia (heart rate > 100 beats/min) | 8 (36) |
| Nausea | 6 (27) |
| Vomiting | 2 (9) |
| Dizziness | 2 (9) |
| Bleeding | 1 (4) |
| Hypotension (blood pressure < 90/50 mm Hg) | 1 (4) |
| Alteplase (n = 5) | |
| Acute intramuscular hemorrhage | 1 (20) |
| Bleeding from wounds | 1 (20) |
↵* As of 2017.