Variable | No. (%) of patients |
---|---|
Treatment | |
Rapid rewarming | 13 (59) |
Iloprost only | 9 (41) |
Iloprost, alteplase and heparin | 4 (18) |
Passive rewarming | 9 (41) |
Iloprost only | 8 (36) |
Iloprost, alteplase and heparin | 1 (4) |
Treatment adjunct | |
Topically administered aloe vera | 19 (86) |
Scheduled orally administered ibuprofen | 22 (100) |
No. of iloprost doses received | |
1 | 2 (9) |
3 | 3 (14) |
4 | 1 (5) |
5 | 16 (73) |
Alteplase dosing (n = 5) | |
15 mg intravenously over 2 min, then 0.75 mg/kg (maximum 50 mg) over 30 min, then 0.5 mg/kg (maximum 35 mg) over 60 min | 1 (20) |
0.15 mg/kg over 15 min, then 0.15 mg/kg per hour intravenously for 6 h* | 4 (80) |
Adverse drug reactions | |
Iloprost | |
Headache | 11 (50) |
Flushing | 8 (36) |
Tachycardia (heart rate > 100 beats/min) | 8 (36) |
Nausea | 6 (27) |
Vomiting | 2 (9) |
Dizziness | 2 (9) |
Bleeding | 1 (4) |
Hypotension (blood pressure < 90/50 mm Hg) | 1 (4) |
Alteplase (n = 5) | |
Acute intramuscular hemorrhage | 1 (20) |
Bleeding from wounds | 1 (20) |
↵* As of 2017.