Table 3:

Risk of bias assessment

StudySelection biasAscertainment biasCausalityQuality of reporting, description
Is (are) the patient(s) representative of the investigating centre?Was the exposure/ outcome adequately ascertained?Was an alternative cause ruled out?Was there a challenge– rechallenge phenomenon?Was there a dose– response effect?Was follow-up long enough?Was (were) the case(s) described in sufficient detail?
O’Reilly et al.28Patient selection method NSYes/yesYesNoNoYesYes
Denkler and Cohen43Patient selection method NSYes/yesYesNoNoYesYes
Wong et al.40Patient selection method NSYes/yesYesNoNoYesYes
Varughese and Koh41Patient selection method NSYes/yesYesNoNoYesYes
Baserga et al.25Patient selection method NSYes/yesYesNoNoYesYes
Vasquez et al.30Patient selection method NSYes/yesYesNoNoYesYes
Maffei et al.23Patient selection method NSYes/yesYesNoNoYesYes
Ancora et al.39Patient selection method NSYes/yesYesNoNoYesYes
Mousavi et al.38Patient selection method NSNSYesNoNoYesYes
Akingbola et al.34Patient selection method NSYes/yesYesYesNoYesYes
Mosalli et al.35Patient selection method NSYes/yesYesNoNoYesYes
Kamar et al.44Patient selection method NSYes/sesYesNoNoYesYes
Samiee-Zafarghandy et al.22Patient selection method NSYes/yesYesNoNoYesYes
Dilli et al.33Patient selection method NSYes/yesYesNoNoYesYes
Teo and Shah31Patient selection method NSYes/yesYesNoNoYesYes
Parra et al.29Patient selection method NSYes/yesYesNoNoYesYes
Vivar del Hoyo et al.24Patient selection method NSYes/yesYesNoNoYesYes
Yong et al.42YesYes/yesYesNoNoYesYes
Han et al.37Patient selection method NSYes/yesYesNoNoYesYes
Isik et al.36Patient selection method NSYes/yesYesNoNoYesYes
Mintoft et al.26Patient selection method NSYes/yesYesNoNoYesYes
Kuttysankaran et al.32Patient selection method NSYes/yesYesNoNoYesYes
Weeraskera et al.27Patient selection method NSYes/yesYesNoNoYesYes
  • Note: NS = not stated. Risk of bias was ascertained using the Tool for Evaluating the Methodological Quality of Case Reports and Case Series.21