Characteristics of the study population
| Characteristic | Sex; study group;* no. (%) of participants† | |||||
|---|---|---|---|---|---|---|
| Women | Men | |||||
| Manitoba n = 560 102 | Cases n = 19 017 | Controls n = 94 566 | Manitoba n = 544 672 | Cases n = 34 393 | Controls n = 170 291 | |
| Age at diagnosis, yr, mean (95% CI) | 44.9 (44.8–44.9) | 38.3 (38.1–38.6) | 38.3 (38.2–38.4) | 43.1 (43.0–43.1) | 42.2 (42.0–42.4) | 42.2 (42.1–42.3) |
| Age group, yr | NA | NA | ||||
| 12–17 | 2184 (11.5) | 11 030 (11.7) | 1915 (5.6) | 11 097 (6.5) | ||
| 18–24 | 3687 (19.4) | 18 232 (19.3) | 5791 (16.8) | 27 537 (16.2) | ||
| 25–29 | 2086 (11.0) | 10 232 (10.8) | 3276 (9.5) | 15 517 (9.1) | ||
| 30–34 | 1876 (9.9) | 9346 (9.9) | 3202 (9.3) | 15 465 (9.1) | ||
| 35–39 | 1549 (8.1) | 7704 (8.2) | 2970 (8.6) | 14 668 (8.6) | ||
| 40–44 | 1475 (7.8) | 7356 (7.8) | 2792 (8.1) | 14 034 (8.2) | ||
| 45–49 | 1231 (6.5) | 6133 (6.5) | 2678 (7.8) | 13 226 (7.8) | ||
| 50–54 | 972 (5.1) | 4870 (5.2) | 2370 (6.9) | 12 002 (7.0) | ||
| 55–59 | 775 (4.1) | 3852 (4.1) | 2183 (6.3) | 10 962 (6.4) | ||
| 60–64 | 684 (3.6) | 3431 (3.6) | 1869 (5.4) | 9316 (5.5) | ||
| 65–69 | 654 (3.4) | 3232 (3.4) | 1792 (5.2) | 8965 (5.3) | ||
| 70–74 | 560 (2.9) | 2789 (3.0) | 1458 (4.2) | 7182 (4.2) | ||
| 75–79 | 548 (2.9) | 2735 (2.9) | 1091 (3.2) | 5412 (3.2) | ||
| 80–84 | 383 (2.0) | 1889 (2.0) | 631 (1.8) | 3103 (1.8) | ||
| 85–89 | 247 (1.3) | 1224 (1.3) | 294 (0.9) | 1429 (0.8) | ||
| ≥ 90 | 106 (0.6) | 511 (0.5) | 81 (0.2) | 376 (0.2) | ||
| Urban residence | 353 506 (63.1) | 10 527 (55.4) | 52 477 (55.5) | 336 087 (61.7) | 18 940 (55.1) | 94 347 (55.4) |
| Income quintile | ||||||
| Urban 1 (lowest) | 68 287 (12.2) | 4326 (22.7) | 21 607 (22.8) | 64 495 (11.8) | 6727 (19.6) | 33 586 (19.7) |
| Urban 2 | 70 370 (12.6) | 2131 (11.2) | 10 634 (11.2) | 66 222 (12.2) | 4109 (11.9) | 20 519 (12.0) |
| Urban 3 | 69 913 (12.5) | 1661 (8.7) | 8290 (8.8) | 66 089 (12.1) | 3230 (9.4) | 16 113 (9.5) |
| Urban 4 | 69 155 (12.3) | 1167 (6.1) | 5813 (6.1) | 67 598 (12.4) | 2541 (7.4) | 12 654 (7.4) |
| Urban 5 (highest) | 70 751 (12.6) | 955 (5.0) | 4774 (5.0) | 68 231 (12.5) | 1958 (5.7) | 9777 (5.7) |
| Rural 1 (lowest) | 38 419 (6.9) | 3096 (16.3) | 15 343 (16.2) | 38 845 (7.1) | 4976 (14.5) | 24 248 (14.2) |
| Rural 2 | 41 532 (7.4) | 1879 (9.9) | 9337 (9.9) | 41 626 (7.6) | 3244 (9.4) | 15 925 (9.4) |
| Rural 3 | 42 333 (7.6) | 1193 (6.3) | 5912 (6.3) | 42 326 (7.8) | 2543 (7.4) | 12 641 (7.4) |
| Rural 4 | 41 124 (7.3) | 1216 (6.4) | 6063 (6.4) | 41 872 (7.7) | 2383 (6.9) | 11 794 (6.9) |
| Rural 5 (highest) | 41 876 (7.5) | 1053 (5.5) | 5251 (5.6) | 42 813 (7.9) | 2230 (6.5) | 11 087 (6.5) |
| Unknown | 6342 (1.1) | 340 (1.8) | 1542 (1.6) | 4555 (0.8) | 452 (1.3) | 1947 (1.1) |
| RUB | ||||||
| 0 (non-users) | 89 515 (16.0) | 6209 (32.6) | 31 197 (33.0) | 156 053 (28.7) | 15 728 (45.7) | 77 863 (45.7) |
| 1 (lowest morbidity) | 54 857 (9.8) | 687 (3.6) | 6710 (7.1) | 55 758 (10.2) | 1322 (3.8) | 10 619 (6.2) |
| 2 | 139 029 (24.8) | 2707 (14.2) | 19 234 (20.3) | 133 932 (24.6) | 4738 (13.8) | 29 650 (17.4) |
| 3 | 248 581 (44.4) | 7757 (40.8) | 33 718 (35.7) | 175 721 (32.3) | 10 361 (30.1) | 45 652 (26.8) |
| 4 | 23 898 (4.3) | 1416 (7.4) | 3191 (3.4) | 19 391 (3.6) | 1872 (5.4) | 5467 (3.2) |
| 5 (highest morbidity) | 4222 (0.8) | 241 (1.3) | 516 (0.5) | 3817 (0.7) | 372 (1.1) | 1040 (0.6) |
| Mental disorder | ||||||
| Mood or anxiety disorder | 155 809 (27.8) | 9809 (51.6) | 19 428 (20.5) | 85 360 (15.7) | 10 724 (31.2) | 18 608 (10.9) |
| Personality disorder | 18 009 (3.2) | 1226 (6.4) | 723 (0.8) | 13 998 (2.6) | 1330 (3.9) | 1035 (0.6) |
| Psychosis | 8633 (1.5) | 1269 (6.7) | 1541 (1.6) | 8394 (1.5) | 2218 (6.4) | 2678 (1.6) |
Note: AUD = alcohol use disorder, CI = confidence interval, NA = not available, RUB = Johns Hopkins Resource Utilization Band.
↵* Cases = people with diagnosis of AUD who were included in the study; controls = people without diagnosis of AUD who were included in the study.
↵† Except where indicated otherwise.