Availability of pediatric information in drug monographs by therapeutic class and indications
| Therapeutic class | Monographs presenting pediatric indications, by age group | Indications of drugs approved for adults with no pediatric information* | |||||||
|---|---|---|---|---|---|---|---|---|---|
| 12–17 yr | 6–11 yr | 2–5 yr | 28 d–1 yr | Neonates | Preterm | Age not specified | Total | ||
| Allergy or immunology | 8 | 7 | 7 | 4 | 0 | 0 | 1 | 10 | Crohn disease, plaque psoriasis, seasonal allergic rhinitis or conjunctivitis, systemic lupus erythematosus, ulcerative colitis |
| Anesthesia or analgesia | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | Intensive care unit sedation, severe pain, topical analgesia |
| Cardiology | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | Arrhythmia, atrial fibrillation, dyslipidemia, familial hypercholesteremia, heart failure, hypertension, perioperative hypertension, pulmonary arterial hypertension |
| Dermatology | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | Actinic keratosis, basal cell carcinoma, eczema, rosacea |
| Diagnostic imaging | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | Hepatic or cardiac vascular imaging |
| Endocrine or metabolic | 10 | 10 | 10 | 8 | 2 | 0 | 0 | 10 | Cushing syndrome, diabetes, lipodystrophy |
| Gastrointestinal | 3 | 2 | 2 | 1 | 1 | 0 | 0 | 3 | Chronic idiopathic constipation, cirrhosis, irritable bowel syndrome, opioid-induced constipation, nausea or vomiting |
| Hematology | 8 | 7 | 7 | 3 | 1 | 0 | 3 | 11 | Anemia, embolism treatment and prevention, hemostasis, stroke prevention, thrombocytopenic purpura, polycythemia vera |
| Infectious disease | 17 | 13 | 10 | 7 | 1 | 1 | 0 | 18 | Clostridium difficile infection, hepatitis C, human immunodeficiency virus, intra-abdominal infections, invasive systemic fungal infections, methicillin-resistant Staphylococcus aureus infections, onychomycosis, pneumonia, skin infections |
| Nephrology | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | Hyponatremia |
| Neurology | 3 | 2 | 2 | 0 | 0 | 0 | 1 | 4 | Parkinson disease, dementia, partial-onset seizures, restless leg syndrome, relapsing remitting multiple sclerosis, reversal of neuromuscular blockade |
| Obstetrics or gynecology | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | Uterine fibroids, vasomotor symptoms associated with menopause |
| Oncology | 4 | 4 | 3 | 2 | 0 | 0 | 1 | 4 | Acute lymphoblastic leukemia, breast cancer, Castleman disease, chronic lymphocytic leukemia, chronic myelogenous leukemia, colorectal cancer, gastric cancer, hepatocellular carcinoma, leukemia, lymphoma, melanoma, multiple myeloma, non-small cell lung carcinoma, ovarian cancer, renal cell carcinoma, soft tissue sarcoma, prostate cancer |
| Ophthalmology | 2 | 2 | 2 | 1 | 0 | 0 | 0 | 2 | Actinic keratosis, age-related macular degeneration, ocular pain, open angle glaucoma, postoperative inflammation |
| Psychiatry | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | Anxiety, maintenance of alcohol abstinence, antipsychotics, major depressive disorder |
| Pulmonology | 5 | 3 | 2 | 0 | 0 | 0 | 0 | 5 | Chronic obstructive pulmonary disease, chronic bronchitis, emphysema, asthma, idiopathic pulmonary fibrosis |
| Rheumatology | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | Gout, psoriatic arthritis, rheumatoid arthritis |
| Urology | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | Benign prostatic hyperplasia, overactive bladder |
| Total | 68 | 55 | 47 | 27 | 7 | 1 | 6 | 75 | |
* For no. of drug monographs that do not present pediatric indications (per therapeutic class), see Table 1.