Table 1:

Performance of Nitrostat (nitroglycerin, Pfizer) tablets stored in varying packaging configurations (n = 6)

	Week^*^†

	1		2		4		8		12		24

Experimental storage condition	F2	S/NS	F2	S/NS	F2	S/NS	F2	S/NS	F2	S/NS	F2	S/NS
Control: original borosilicate glass packaging, RT

PTFE insert, PTFE cap, RT	64.6	S	69.4	S	84.6	S	86.6	S	87.6	S	52.4	S

Borosilicate glass insert, PTFE cap, RT	46.9	NS	59.8	S	66.1	S	69.5	S	85.8	S	58.7	S

PTFE insert, PTFE cap, 4°C	68.5	S	76.1	S	67.4	S	68.9	S	80.1	S	58.6	S

Borosilicate glass insert, PTFE cap, 4°C	53.2	S	59.6	S	75.6	S	85.0	S	73.5	S	62.9	S

PTFE insert, PTFE cap, 35°C	62.3	S	78.2	S	71.1	S	95.1	S	64.8	S	61.8	S

Borosilicate glass insert, PTFE cap, 35°C	46.7	NS	71.4	S	64.1	S	82.2	S	58.1	S	26.4	NS

PTFE insert, PE cap, 35°C	77.4	S	82.3	S	44.3	NS	46.3	NS	45.0	NS	30.2	NS

PTFE insert, PTFE cap, 35°C, N₂ packaging	58.8	S	78.7	S	65.1	S	75.7	S	84.2	S	37.1	NS

Borosilicate glass insert, PTFE cap, 35°C, N₂ packaging	55.0	S	61.2	S	75.8	S	62.0	S	77.1	S	31.1	NS

PTFE insert, PTFE cap, −20°C	–	–	–	–	60.1	S	–	–	–	–	–	–

PTFE insert, PTFE cap, 0.3-mg, RWC	–	–	–	–	–	–	–	–	–	–	56.0	S

PTFE insert, PTFE cap, 0.6-mg, RWC	–	–	–	–	–	–	–	–	–	–	49.9

NS Note: N₂ = nitrogen, NS = not similar, PE = polyethylene, PTFE = polytetrafluoroethylene, RT = room temperature, RWC = real-world conditions, S = similar.
↵* F2 values less than 50 indicate significant differences in the release profiles.
↵† Red letters indicate results for the marketed product components and configuration of the SMHeartCard.