Table 2:

Characteristics of included primary studies (reviews 1 and 2)

Investigator (review)	Study design	Eligibility criteria	Country	Study period	Total sample size	Source of funding	Study quality
Brown et al., 201520 (review 1)	Retrospective cohort	Trans-related diagnosis (i.e., gender identity disorder, gender identity disorder not otherwise specified, transvestic fetishism, transsexualism) Veteran Accessed medical and mental health services at VHA facility	United States	17 yr (Oct. 1, 1996, to Sept. 30, 2013)	5135	Authors employed by VHA No grant or commercial funding	Fair^*
Gooren et al., 201321 (review 1)	Retrospective cohort	Trans person Minimum 6-yr follow-up	The Netherlands	38 yr (1975 to Dec. 31, 2012)	3102	Two authors received noncommercial support	Fair^*
Weyers et al., 201023 (review 2)	Cross-sectional	Dutch-speaking trans women Received sex reassignment surgery at least 6 mo before enrolment Consulted Ghent University Hospital gender team during previous 12 mo	Belgium	4 mo (Mar–June 2007)	50	First author received commercial support	Poor^†
Kuroda et al., 200822 (review 1)	Retrospective cohort	Trans men Underwent mastectomy at surgical institute	Japan	9 yr (1998–2006)	186	NR	Poor^*

Note: NR = not reported, VHA = Veterans Health Administration.
↵* Assessed with the Newcastle–Ottawa Scale.16,33 Detailed results of the quality assessment are provided in Supplementary Table S2, Appendix 4 (available at www.cmajopen.ca/content/7/3/E598/suppl/DC1).
↵† No formal critical appraisal tool was used; methodological quality was assessed by considering key methodological components such as the selection of participants, and exposure and outcome assessments.
Detailed results of the quality assessment are provided in Supplementary Table S3, Appendix 4.